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PET/CT Imaging for Heart Function in Lung Cancer
N/A
Recruiting
Led By Yevgeniy Vinogradskiy
Research Sponsored by Thomas Jefferson University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 30 months after radiotherapy
Awards & highlights
Study Summary
This trial studies if PET/CT scans can help detect changes in heart function due to radiation therapy in lung cancer patients.
Who is the study for?
This trial is for adults with pathologically confirmed lung cancer who are about to undergo radiation therapy and have a life expectancy of at least 3 months. They must consent to the study's procedures, be available throughout, and receive a heart dose of radiation estimated at 5 Gy or more. It excludes those on palliative radiation doses or with contraindications for FDG PET-CT scans.Check my eligibility
What is being tested?
The EUCLID Trial is testing the use of PET/CT imaging to detect potential cardiac damage from radiation treatment in lung cancer patients. The goal is to monitor heart function before, during, and after radiotherapy using this imaging technique which can highlight inflammation and tissue viability.See study design
What are the potential side effects?
Since this trial involves diagnostic imaging rather than medication, side effects are minimal but may include discomfort from lying still during the scan or reactions related to contrast agents used in PET/CT such as allergic reactions or metallic taste.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 30 months after radiotherapy
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 30 months after radiotherapy
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in mean standardized uptake value (SUV) changes in the heart
Secondary outcome measures
Ability of pre- to post-radiotherapy SUV changes in the heart
Cardiac related death
Cardiac toxicity
+2 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Diagnostic (sarcoidosis FDG PET-CT)Experimental Treatment4 Interventions
Patients undergo sarcoidosis FDG PET-CT of the heart before, during and, after radiotherapy.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Positron Emission Tomography
2008
Completed Phase 2
~2210
Computed Tomography
2017
Completed Phase 2
~2720
Find a Location
Who is running the clinical trial?
Thomas Jefferson UniversityLead Sponsor
446 Previous Clinical Trials
147,937 Total Patients Enrolled
Yevgeniy VinogradskiyPrincipal InvestigatorThomas Jefferson University
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am 18 years old or older.My heart is expected to receive a radiation dose of 5 Gy or more.I received a specific low-dose radiation treatment.I am willing and able to follow all study rules and attend all appointments.I am scheduled for radiation therapy for lung or esophageal cancer.My lung or esophageal cancer has been confirmed by a lab test.
Research Study Groups:
This trial has the following groups:- Group 1: Diagnostic (sarcoidosis FDG PET-CT)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the current enrollment size of this clinical trial?
"Affirmative. The clinicaltrials.gov website lists this trial as actively recruiting with a starting date of January 20th, 2022 and an update on March 7th, 2023. It is looking to admit twenty individuals across one research site."
Answered by AI
Are there any opportunities for participants to join this experiment now?
"Affirmative, clinicaltrials.gov reports that this medical trial is actively recruiting patients and was initially posted on January 20th 2023 before the most recent edit made on March 7th of the same year. The research requires recruitment of a total of twenty individuals from one location."
Answered by AI
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