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HEPA Filter
Air Purification for Eosinophilic COPD
N/A
Waitlist Available
Led By Mary B Rice, MD MPH
Research Sponsored by Beth Israel Deaconess Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Physician diagnosis of COPD [Global Initiative for Obstructive Lung Disease (GOLD) Stage II-IV disease with Forced Expiratory Volume (FEV1)/ Forced Vital Capacity (FVC) ≤70% and FEV1 (% predicted) <80%]
Age of 40 years or more
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline [3 months before intervention and day of intervention] and post intervention [7 days, 6 months and 12 months]
Awards & highlights
Study Summary
This trial will study whether air purifiers help improve the lung health of people with COPD who have eosinophils in their airways.
Who is the study for?
Adults over 40 with eosinophilic COPD, a history of smoking (at least 10 pack-years), and specific lung function test results can join. They must not already use HEPA air purifiers, live in long-term care, plan to move soon, or have severe diseases with less than 2 years life expectancy.Check my eligibility
What is being tested?
The trial is testing if home air purifiers improve lung health in people with eosinophilic COPD. Participants are randomly divided into two groups: one gets real HEPA filter air purifiers and the other gets fake ones.See study design
What are the potential side effects?
Since this trial involves using an air purifier versus a sham device, there are no direct medical side effects expected from the interventions themselves.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have been diagnosed with moderate to severe COPD.
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I am 40 years old or older.
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I have smoked the equivalent of 10 or more packs of cigarettes per year.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline [3 months before intervention and day of intervention] and post intervention [7 days, 6 months and 12 months]
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline [3 months before intervention and day of intervention] and post intervention [7 days, 6 months and 12 months]
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in forced expiratory volume in 1 second (FEV1)
Secondary outcome measures
Change in functional capacity by 6 minute walk test
Change in health status (also called health-related quality of life) by St. George Respiratory Questionnaire
Change in respiratory symptoms
Other outcome measures
Change in nasal inflammatory mediators
Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: True air purifierExperimental Treatment1 Intervention
Participants will receive a HEPA air purifier in the bedroom and living room.
Group II: Sham air purifierPlacebo Group1 Intervention
Participants will receive a sham air purifier that will be installed in the bedroom and living room. These purifiers will make a noise, but will not filter the air.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Air purifier
2017
N/A
~190
Find a Location
Who is running the clinical trial?
Beth Israel Deaconess Medical CenterLead Sponsor
838 Previous Clinical Trials
13,010,332 Total Patients Enrolled
National Institute of Environmental Health Sciences (NIEHS)NIH
284 Previous Clinical Trials
1,232,577 Total Patients Enrolled
Mary B Rice, MD MPHPrincipal InvestigatorBeth Israel Deaconess Medical Center
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My doctor thinks I have less than 2 years to live due to a severe illness.I cannot perform lung function tests.I have been diagnosed with moderate to severe COPD.I am 40 years old or older.You use a special air filter machine called a portable HEPA air purifier at your home regularly.I have smoked the equivalent of 10 or more packs of cigarettes per year.
Research Study Groups:
This trial has the following groups:- Group 1: Sham air purifier
- Group 2: True air purifier
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are individuals being accepted into this research study at the present moment?
"Clinicaltrials.gov reveals that this medical trial is no longer enrolling participants, as the post was first created on March 15th 2021 and last edited November 3rd 2022. Nonetheless, there are still 279 other studies seeking candidates for their clinical trials."
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