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Brain Imaging for Concussion in Former NFL Players
Study Summary
This trialstudies brain health of former NFL players to see if concussions and sub-concussive exposure causes long-term effects. It uses detailed tests, such as MRI and PET, to understand and help those at risk.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
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- I am between 50 and 70 years old.I have never played football, collision sports, or had a concussion.I will be matched with former NFL players based on age and estimated intellectual ability before any brain injury.
- Group 1: Low Cognitive Functioning/Medium Concussion History
- Group 2: High Cognitive Functioning/Low Concussion History
- Group 3: Low Cognitive Functioning/Low Concussion History
- Group 4: Low Cognitive Functioning/High Concussion History
- Group 5: Healthy Male Controls
- Group 6: Medium Cognitive Functioning/Low Concussion History
- Group 7: Medium Cognitive Functioning/High Concussion History
- Group 8: High Cognitive Functioning/Medium Concussion History
- Group 9: High Cognitive Functioning/ High Concussion History
- Group 10: Medium Cognitive Functioning/Medium Concussion History
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How large is the current cohort for this clinical research?
"Unfortunately, no further participants are needed for this trial; it was initially posted on March 12th 2020 and the most recent update was November 23rd 2022. However, there are currently 76 different trials recruiting patients with concussion or brain issues and 2 distinct studies for this intervention that still require enrolment."
Has this treatment been tested in other medical experiments?
"The therapeutic intervention was initially investigated in 2018 by Mayo Clinic. At present, two completed studies and two active trials exist; a considerable portion of these are administered out of Chapel Hill, North carolina."
May I participate in this research experiment?
"Admission to this medical trial requires that participants have experienced a concussion, possess healthy brain tissue and fall in between the ages of 50-70. 250 individuals are needed for successful enrolment."
Is this investigation actively looking for older adults to join the trial?
"This clinical trial has a narrow age requirement, seeking out patients between 50 and 70. There are separate studies for those younger than 18 or older than 65 with 26 and 35 trials respectively."
Is there an open window for enrolling in this analysis?
"According to clinical trials.gov, this medical trial is not presently recruiting participants. Initially posted on March 12th 2020 and last updated on November 23rd 2022, the study has yet to accept any patients; however 78 other studies are actively enrolling at this time."
Is this remedy risk-free for individuals?
"Our internal evaluation gives this treatment a rating of 1 due to the few data points available in Phase 1 trials that support its efficacy and safety."
What purport does this research endeavor to achieve?
"The primary outcome sought by this clinical trial, to be measured at the baseline is Radial Diffusivity (RD) as derived from Tract-Based Diffusion. Secondary outcomes encompass Alcohol Use Disorders Identification Test (AUDIT), National Institute of Health Toolbox Cognitive Battery and Drug Abuse Screening Test-10 (DAST-10). These tests evaluate hazardous alcohol use, dependence symptoms, cognitive functioning and drug abuse over a 3 year followup respectively with scores ranging from 0 - 40 for AUDIT, infinite range for NIHTBXCogBatt and 0 - 10 for DAST-10."
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