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Radiation Therapy

MR-Guided Radiation + Chemotherapy for Pancreatic Cancer

Phase 2

Waitlist Available

Led By Beth Erickson, MD

Research Sponsored by Medical College of Wisconsin

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Pathologically confirmed (histologic or cytologic), locally advanced, adenocarcinoma of the pancreas; patients must have unresectable disease based on institutional standardized criteria of unresectability or medical inoperability

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 and 2 years

Awards & highlights

Study Summary

This trial is for people with pancreatic cancer who are ineligible for surgery. To be eligible, patients must have received several months of chemotherapy and their tumor must not have progressed on imaging studies.

Who is the study for?

This trial is for adults with advanced pancreatic cancer that can't be removed by surgery. They should have completed at least 4 months of chemotherapy without the cancer spreading, as confirmed by imaging. Participants need to be able to swallow pills and use effective contraception if applicable.Check my eligibility

What is being tested?

The study tests a combination of dose-escalated radiation therapy guided by magnetic resonance (MR) imaging alongside concurrent chemotherapy drugs Gemcitabine and Capecitabine in patients who are not candidates for surgical treatment of their pancreatic cancer.See study design

What are the potential side effects?

Potential side effects may include skin changes or irritation where the radiation is aimed, fatigue, nausea, vomiting, diarrhea from chemotherapy, and increased risk of infections due to lowered blood cell counts.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My pancreatic cancer is advanced and cannot be removed with surgery.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 and 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 and 2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Overall Survival

Secondary outcome measures

Efficacy of dose escalation

Progression Free Survival

Radiation induced toxicity

+4 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Radiation therapy plus chemotherapyExperimental Treatment2 Interventions

MR guided dose escalated radiation therapy plus concurrent chemotherapy in unresectable non-metastatic pancreas cancer. Radiation therapy dose escalation to an MR-defined GTV of up to 69.75 Gy at 2.25 Gy per fraction and concurrent Gemcitabine or Capecitabine.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Radiation Therapy

2017

Completed Phase 3

~7250

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor

610 Previous Clinical Trials

1,162,690 Total Patients Enrolled

Beth Erickson, MDPrincipal Investigator - Froedtert & The Medical College of Wisconsin

Froedtert & The Medical College of Wisconsin

Medical College Of Wisconsin (Medical School)

Medical College Wi Affil Hosps, Inc (Residency)

Media Library

Magnetic Resonance Guided Radiation Therapy (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT01972919 — Phase 2

Pancreatic Cancer Research Study Groups: Radiation therapy plus chemotherapy

Pancreatic Cancer Clinical Trial 2023: Magnetic Resonance Guided Radiation Therapy Highlights & Side Effects. Trial Name: NCT01972919 — Phase 2

Magnetic Resonance Guided Radiation Therapy (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01972919 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are people still being enrolled in this experiment?

"Yes, this study is recruiting patients as of now. Its original posting was on December 10th, 2015 with the latest update being September 1st, 2022."

Answered by AI

For what sorts of medical conditions is Radiation Therapy regularly recommended?

"While most commonly used to treat urinary bladder, radiation therapy can also ameliorate refractory fallopian tube carcinoma, small cell lung cancer (sclc), and head and neck carcinoma."

Answered by AI

What is the FDA's stance on Radiation Therapy?

"While there is some evidence to support the safety of radiation therapy, it received a score of 2 because this treatment has not yet been proven effective."

Answered by AI

What is the ceiling for recruitment in this experiment?

"That is correct, the clinical trial is currently underway. 23 patients need to be recruited from a single location. The information on clinicaltrials.gov says that this trial was first posted on December 10th, 2015 and was last edited September 1st, 2022."

Answered by AI

What are the most recent findings from research on Radiation Therapy?

"There are 785 ongoing studies into Radiation Therapy, 253 of which have reached Phase 3. Many of these trials are based in Guangzhou, Guangdong; however, there are 36027 total locations running research for this treatment method."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Magnetic Resonance (MR) Guided, Dose-Escalated Radiation Therapy (RT) + Chemotherapy in Pancreatic Cancer

Beth Erickson 2015. "Magnetic Resonance (MR) Guided, Dose-Escalated Radiation Therapy (RT) + Chemotherapy in Pancreatic Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01972919.