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Combination Therapy for Lung Cancer (CHORUS Trial)
CHORUS Trial Summary
This trial is testing a new combination treatment for people with NSCLC.
CHORUS Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowCHORUS Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.CHORUS Trial Design
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Who is running the clinical trial?
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- My lung cancer was confirmed by a pathology review at MSK.I have not received a live vaccine in the last 3 months.I am 18 years old or older.I have received an organ transplant from another person.My blood counts and liver/kidney functions are within the required ranges.I haven't had certain immune-targeting drugs or antibodies in the last 4 weeks.I cannot have surgery for my condition as advised by doctors.I am eligible for a specific chest radiation therapy.I cannot take Durvalumab due to health reasons.I have or had an autoimmune or inflammatory disorder.I have not had major surgery in the last 28 days.My doctors agree I should have chemotherapy and radiation at the same time.I do not have severe illnesses like heart disease, liver problems, TB, HIV, lung disease, or addiction.I can sign and will follow the study's rules as explained in the consent form.My lung cancer is at stage IIIA-C.I am not pregnant or breastfeeding and willing to use effective birth control during and up to 130 days after treatment.I haven't had or treated any cancer other than NSCLC in the last 3 years.My body weight is over 30 kg.You have a known history of a weakened immune system that you were born with.I've had chest radiation that prevents me from getting more targeted radiation therapy.I am willing and able to follow the study's treatment plan and attend all visits.You are expected to live for at least 6 more months.I am currently being treated for a lung or esophagus connective tissue disorder or have idiopathic pulmonary fibrosis.I haven't taken any immune-weakening drugs in the last 14 days.I am fully active or can carry out light work.I am post-menopausal or have a negative pregnancy test if pre-menopausal.
- Group 1: Canakinumab with Chemoradiation and Durvalumab
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is this research inquiry being conducted in multiple Canadian locations?
"This research is currently being conducted at 7 distinct loci, which encompasses the cities of Harrison, Middletown and Montvale in addition to four other urban centres. It may be prudent for prospective participants to choose a location that is nearby in order to reduce travel burdens."
Are there any other research projects that have employed Chemotherapy?
"The origins of chemotherapy can be traced back to 2010 with the City of Hope's pioneering work. Since then, there have been 291 clinical trials completed and an additional 348 are underway; many in Harrison, New jersey."
What maladies can be addressed with Chemotherapy?
"Unresectable Stage III Non-Small cell lung cancer is typically managed with chemotherapy, a therapy that has been found to effectively tackle conditions like Juvenile Idiopathic Arthritis and Neonatal-Onset Multisystem Inflammatory Disease (NOMID)."
What potential hazards should be considered when using Chemotherapy?
"Although there is a dearth of evidence that chemotherapy works, data showing its safety has been collected. Therefore, it received an overall rating of 2."
How many participants are currently partaking in this trial?
"Affirmative. According to the information present on clinicaltrials.gov, this trial is currently recruiting participants after it was unveiled on May 21st 2021 and updated most recently on August 15th 2022. Specifically, 32 individuals will be accepted across seven different sites."
Is enrollment for this experiment open at the moment?
"Yes, the clinicaltrial.gov page shows that this trial is actively enrolling patients. It was published on May 21st 2021 and the latest update occured on August 15th 2022. 32 individuals are sought out from 7 different medical centres for participation in this study."
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