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MK2206 + Hydroxychloroquine for Advanced Cancers
Study Summary
This trial is testing the side effects and best dose of Akt inhibitor MK2206 with hydroxychloroquine in treating patients with advanced solid tumors, melanoma, prostate or kidney cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2015 Phase 2 trial • 37 Patients • NCT01307631Trial Design
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Who is running the clinical trial?
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- I am fully active and can carry on all pre-disease activities without restriction.I can swallow and retain medication without issues.I am not pregnant or nursing.I am HIV-positive and not on antiretroviral therapy.I have a liver condition like cirrhosis or chronic hepatitis.My heart's electrical cycle is normal and I'm not on QT-prolonging drugs.I do not have any severe illnesses or social situations that would interfere with the study.I do not have active brain metastases and have not needed steroids for them in over 2 months.My diabetes is not under control, with high blood sugar or HbA1c levels.I do not have psoriasis or porphyria.I have recovered from any side effects of my previous cancer treatments.My kidney function is within the required range for the trial.I have advanced cancer and have tried at least one standard treatment or have no standard treatments available.Your platelet count is at least 100,000 per microliter within the last 7 days before starting treatment.Patients must have a way to measure or evaluate their disease according to specific criteria.I agree to use birth control during and 6 months after the study.An eye doctor has approved me for hydroxychloroquine after a screening.I can swallow tablets whole without needing to crush or chew them.I do not have a G-6PD deficiency.I am currently being treated for rheumatoid arthritis or lupus.I am diabetic and use insulin to control my blood sugar.Your bilirubin levels are normal according to the lab's standards.I am not currently on any experimental treatments besides this study.I am not taking hydroxychloroquine for malaria.I am not pregnant, am post-menopausal, or have been surgically sterilized.You cannot be allergic to a specific type of medication called 4-aminoquinoline compound.You have had allergic reactions to drugs that are similar to the ones used in this study.Your white blood cell count needs to be above a certain number.Your white blood cell count is at least 3,000 cells per microliter.I haven't fully recovered from side effects of treatments or surgeries done over 4 weeks ago.You are expected to live for at least 12 more weeks.I have no eye damage from previous 4-aminoquinoline use.I do not have serious heart rhythm problems.I am willing to change medications that affect how a liver enzyme works if needed.Your liver enzymes (AST and ALT) are not more than 2.5 times the normal level.
- Group 1: Treatment (Akt inhibitor MK2206, hydroxychloroquine)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is the research team currently recruiting participants for this experiment?
"This clinical trial has ceased its search for participants. It was initially posted in November of 2011 and closed on July 19th, 2022. For those looking to join an ongoing medical study, presently 2412 trials are recruiting stage iv cutaneous melanoma ajcc v6 & v7 patients and 64 studies requiring Akt Inhibitor MK2206 volunteers are actively enrolling individuals."
How extensive is the cohort in this experiment?
"This clinical trial has paused its recruitment efforts. Originally posted on November 23rd 2011, the study's most recent update was made July 19th 2022. Currently, there are 2412 studies looking for participants with Stage IV Cutaneous Melanoma AJCC v6 and v7 and 64 trials actively recruiting patients to test Akt Inhibitor MK2206."
For what medical purpose is Akt Inhibitor MK2206 primarily prescribed?
"Akt Inhibitor MK2206 has proven to be an effective remedy for malaria, q fever and rheumatoid arthritis."
Has Akt Inhibitor MK2206 achieved regulatory authorization from the Food and Drug Administration?
"Due to the limited clinical data concerning Akt Inhibitor MK2206, we assign it a safety rating of 1 on our scale. This reflects that this is an early phase trial with minimal information confirming its efficacy or safety."
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