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Biomarker

CRP value for Sepsis

N/A
Waitlist Available
Led By Robert Stenstrom, MD, PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Emergency department patients with sepsis: Known or presumed infection and 2 or more SIRS criteria: heart rate > 90/minute; respiratory rate > 20/minute; Oral temperature ≥ 38◦ C or < 36◦ C; white blood cell count > 12,000 or < 4,000.
Able to read and understand consent form in English
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 28 days
Awards & highlights

Study Summary

Patients with sepsis (2 or more systemic inflammatory response syndrome criteria and suspected infection) assessed in the emergency department have blood cultures obtained to identify potential blood stream infections (BSI). Blood cultures are expensive, sometimes inaccurate, and only positive about 10% of the time in the emergency department. This study evaluates the effect of physician knowledge of C-reactive protein (CRP) levels on ordering rates of blood cultures in emergency department patients with sepsis. All patients with sepsis will have CRP levels measured using a point-of-care device, prior to blood tests being ordered. Half of participants will have their CRP level available to the emergency physician and half will not. Blood culture ordering rate and safety outcomes will be compared between these two groups.

Eligible Conditions
  • Sepsis
  • Infections
  • Bacterial Blood Infection

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~28 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Blood culture obtained
Secondary outcome measures
28 day mortality
Admission to hospital
Antibiotic prescribing
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: CRP valueExperimental Treatment1 Intervention
The patients point of care CRP value is known by the treating physician
Group II: CRP value unknownActive Control1 Intervention
The patients point of care CRP value is not known by the treating physician

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,407 Previous Clinical Trials
1,766,341 Total Patients Enrolled
12 Trials studying Sepsis
40,329 Patients Enrolled for Sepsis
Providence Health & ServicesOTHER
115 Previous Clinical Trials
122,315 Total Patients Enrolled
1 Trials studying Sepsis
32 Patients Enrolled for Sepsis
Robert Stenstrom, MD, PhDPrincipal InvestigatorProvidence Health & Services

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~25 spots leftby Mar 2025