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Real NIBS for Cervical Dystonia

N/A
Waitlist Available
Led By Mandar Jog, MD
Research Sponsored by Western University, Canada
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients with cervical dystonia who are already on 3 monthly BoNT-A therapy but the effect of BoNT-A is wearing off in 8 weeks.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Study Summary

Cervical dystonia (CD) is a common movement disorder. Despite the optimization of botulinum toxin injection (BoNT-A) parameters including muscle selection and dosing, a significant proportion of patients report low levels of satisfaction, and a few of them develop resistance to therapy. The only options for such patients would be invasive therapy such as pallidotomy or pallidal deep brain stimulation. Currently, studies are going on the effectiveness of noninvasive neurostimulation in different neurological disorders. Transcranial Direct Current Stimulation (tDCS) or transcranial pulsed current stimulation (tPCS) are known to be safe non-invasive intervention with almost no side effects that can be used to provide complementary treatment. To detect the dysfunctional regions five min resting state quantitative EEG (qEEG) eyes closed will be recorded and analyzed each time before and after noninvasive stimulation. The investigators will evaluate the efficacy of acute noninvasive stimulation in those CD patients who are already on 3 monthly BoNT-A therapy but the effect of BoNT-A is wearing off in 8 weeks. Kinematics (static and dynamic movements) of neck movements will be recorded using established technology before and after stimulation.

Eligible Conditions
  • Cervical Dystonia

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in Network fragmentation using Quantitative Electroencephalography (qEEG)
Changes in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS).
Kinematic changes in angular deviation and amplitude measures

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Real NIBSExperimental Treatment1 Intervention
In Real NIBS arm, active Noninvasive brain stimulation (NIBS) will be given for 20 mins.
Group II: Sham NIBSPlacebo Group1 Intervention
In Sham NIBS arm, sham Noninvasive brain stimulation (NIBS) will be given for 20 mins.

Find a Location

Who is running the clinical trial?

Western University, CanadaLead Sponsor
238 Previous Clinical Trials
57,167 Total Patients Enrolled
2 Trials studying Cervical Dystonia
72 Patients Enrolled for Cervical Dystonia
Mandar Jog, MDPrincipal InvestigatorLondon Health Sciences Centre
7 Previous Clinical Trials
459 Total Patients Enrolled
1 Trials studying Cervical Dystonia
39 Patients Enrolled for Cervical Dystonia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~3 spots leftby Mar 2025