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Amino Acid Supplementation

Amino Acids for Tendinopathy

N/A
Waitlist Available
Led By Chad C Carroll, PhD
Research Sponsored by Purdue University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
21-35 years or 60-80 years old
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0-6 hours post consumption
Awards & highlights

Study Summary

This trial will test if taking amino acids orally will help improve the production of collagen in the Achilles tendon, which may help prevent injuries.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0-6 hours post consumption
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0-6 hours post consumption for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Achilles peritendinous concentrations of pro-collagen
Amino Acid Levels

Side effects data

From 2020 Phase 2 trial • 39 Patients • NCT03273712
95%
Nausea
38%
Vomiting
38%
Fatigue
23%
Abdominal pain
21%
Headache
18%
Anemia
15%
Dizziness
13%
Fever
13%
Infusion site extravasation
13%
Lymphocyte count decreased
10%
Endocrine disorders - Other, specify
10%
White blood cell decreased
10%
Platelet count decreased
8%
Hypertension
8%
Diarrhea
8%
Chills
8%
Neutrophil count decreased
8%
Weight gain
8%
Arthralgia
5%
Pain in extremity
5%
Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify
5%
Constipation
5%
Infections and infestations - Other, specify
5%
Sepsis
5%
Eye disorders - Other, specify
5%
Small intestinal obstruction
5%
Pain
5%
Bronchial infection
5%
Back pain
5%
Dehydration
5%
Hyperkalemia
5%
Myalgia
5%
Anxiety
3%
Musculoskeletal and connective tissue disorder - Other, specify
3%
Flu like symptoms
3%
General disorders and administration site conditions - Other, specify
3%
Insomnia
3%
Flank pain
3%
Vascular disorders - Other, specify
3%
Renal and urinary disorders - Other, specify
3%
Syncope
3%
Gait disturbance
3%
Fall
3%
Alanine aminotransferase increased
3%
Abdominal distension
3%
Localized edema
3%
Urinary tract infection
3%
Lethargy
3%
Memory impairment
3%
Flushing
3%
Atrioventricular block complete
3%
Edema limbs
3%
Catheter related infection
3%
Aspartate aminotransferase increased
3%
Blood bilirubin increased
3%
Creatinine increased
3%
Hyperglycemia
3%
Hypokalemia
3%
Cardiac disorders - Other, specify
3%
Ear and labyrinth disorders - Other, specify
3%
Gastritis
3%
Gastrointestinal disorders - Other, specify
3%
Gastroparesis
3%
Hemorrhoidal hemorrhage
3%
Oral dysesthesia
3%
Upper gastrointestinal hemorrhage
3%
Edema face
3%
Injection site reaction
3%
Non-cardiac chest pain
3%
Hepatobiliary disorders - Other, specify
3%
Skin infection
3%
Investigations - Other, specify
3%
Bone pain
3%
Paresthesia
3%
Peripheral sensory neuropathy
3%
Dyspnea
100%
80%
60%
40%
20%
0%
Study treatment Arm
90Y-DOTA-tyr3-Octreotide

Trial Design

2Treatment groups
Experimental Treatment
Group I: YoungExperimental Treatment1 Intervention
21-30 year old men and women Inclusion/Exclusion Criteria All subjects will be sedentary or recreationally active (sedentary: one day or less per week of aerobic or resistance exercise for at least a year or recreationally active: not training for competitive events). Age: 21-30 years Body mass index <35 kg•m-2, Chronic users of medications such as acetaminophen, ibuprofen, or prescription cyclooxygenase inhibitors will be excluded as these medications have been shown to alter tendon physiology. Individuals with diabetes will be excluded. Diabetes is thought to change the structure of tendon. Individuals with a history of tendon pain will be excluded, as chronic tendon pain is associated with changes in the structure of tendon. Persons with allergies/sentivitiy to amino acids or ingedianet of Cystal Light will be excluded.
Group II: Older AdultsExperimental Treatment1 Intervention
Inclusion/Exclusion Criteria All subjects will be sedentary or recreationally active (sedentary: one day or less per week of aerobic or resistance exercise for at least a year or recreationally active: not training for competitive events). Age: 60-75 years Body mass index <35 kg•m-2 Chronic users of medications such as acetaminophen, ibuprofen, or prescription cyclooxygenase inhibitors will be excluded as these medications have been shown to alter tendon physiology. Individuals with diabetes will be excluded. Diabetes is thought to change the structure of tendon. Individuals with a history of tendon pain will be excluded, as chronic tendon pain is associated with changes in the structure of tendon. Persons with allergies/sentivitiy to amino acids or ingedianet of Cystal Light will be excluded.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Amino Acids
2019
Completed Phase 2
~130

Find a Location

Who is running the clinical trial?

Purdue UniversityLead Sponsor
222 Previous Clinical Trials
72,645 Total Patients Enrolled
Chad C Carroll, PhDPrincipal InvestigatorPurdue University
1 Previous Clinical Trials
20 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could I potentially qualify to take part in this clinical investigation?

"Patients who are of legal age, between 21 and 80 years old, and suffer from tendinitis have the opportunity to join this trial. The study is hoping to recruit a total of 40 participants."

Answered by AI

Is the eligibility for this medical experiment confined to those over 65 years old?

"This clinical trial only accepts participants aged between 21 and 80, in line with its eligibility requisites."

Answered by AI

Are participants being added to this research effort presently?

"According to the clinicaltrials.gov website, this particular trial is no longer recruiting patients since it was last updated on May 31st 2022. That being said, there are 74 other active trials that may be suitable for individuals looking to participate in a medical study."

Answered by AI
~1 spots leftby Mar 2025