← Back to Search

Psychological Stress Intervention for High Blood Pressure (SABRE Trial)

N/A
Waitlist Available
Led By Daichi Shimbo, MD
Research Sponsored by Columbia University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 21 years or older
Age 21 years or older
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 24 hours following laboratory visit.
Awards & highlights

SABRE Trial Summary

This trial will examine how psychological stress affects sodium excretion and blood pressure.

Who is the study for?
This trial is for adults over 21 with high blood pressure (BP) not exceeding 160/105 mm Hg, who can speak English. It's not suitable for those on BP medications or with a history of major medical conditions like cancer, heart disease, stroke, or chronic inflammatory diseases.Check my eligibility
What is being tested?
The study investigates how stress affects the body's handling of salt and its impact on BP patterns. It will explore if stress-related changes in salt excretion during the day are linked to abnormal BP rhythms at night.See study design
What are the potential side effects?
Since this trial involves psychological stress interventions rather than medication, side effects may include temporary increases in stress levels or discomfort related to the intervention process.

SABRE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 21 years old or older.
Select...
I am 21 years old or older.

SABRE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 24 hours following laboratory visit.
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 24 hours following laboratory visit. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Awake-to-sleep ratio of urinary excretion rate
Change in urinary sodium excretion rate with stress
Systolic blood pressure dipping at night
Secondary outcome measures
Mean perceived stress level

SABRE Trial Design

1Treatment groups
Experimental Treatment
Group I: Psychological StressExperimental Treatment1 Intervention
All participants will undergo stress-inducing tasks (psychological stress intervention) using cognitive research tools.

Find a Location

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH
3,815 Previous Clinical Trials
47,292,664 Total Patients Enrolled
Columbia UniversityLead Sponsor
1,426 Previous Clinical Trials
2,473,196 Total Patients Enrolled
Daichi Shimbo, MDPrincipal Investigator - Associate Professor of Medicine, Dept of Med Beh Cardiology
New York Presbyterian Hospital-Columbia Presbyterian Center, Trustees of Columbia University in the City of New York
AlbaNew York Medical College (Medical School)
Mt Sinai School Of Medicine (Residency)
2 Previous Clinical Trials
320 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the aggregate figure of individuals taking part in this clinical experiment?

"Affirmative. According to clinicaltrials.gov, this medical experiment is currently enlisting participants and was first advertised on November 16th 2018. It requires 211 individuals from a single research facility for completion."

Answered by AI

Are any new participants still being admitted to this clinical experiment?

"The online medical database clinicaltrials.gov indicates that this trial, which initially commenced on November 16th 2018, is currently searching for participants. This information was most recently updated on January 12th 2022."

Answered by AI
~33 spots leftby Mar 2025