THC Reduction Group for Suicide

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Tolan Park Medical Building, Detroit, MI
Suicide+5 More
Reduce THC Use - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

This study is looking at therapeutic potential of reducing Tetrahydrocannabinol (THC) levels in regular cannabis smokers using contingency management (CM) intervention in a U.S. veteran population with post-traumatic stress disorder (PTSD).

Eligible Conditions

  • Suicide
  • Post Traumatic Stress Disorder (PTSD)
  • Cannabis Use

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

4 Primary · 9 Secondary · Reporting Duration: Baseline, every 2 weeks for 12 weeks, 3, 6, 12 months post baseline

Baseline
Exploratory analysis of genetic markers associated with endocannabinoid system
Month 12
Change in Brief Pain Inventory
Change in California Verbal Learning Test
Change in Clinician-Administered PTSD Scale for DSM-5 Total Severity Score (CAPS-5)
Change in Columbia Suicide Severity Rating Scale (C-SSRS)
Change in General Health Survey (Short form 36)
Change in Iowa Gambling Task
Change in Quality of Life Inventory
Change in Wisconsin Card Sort Task
Month 12
Change in Beck Depression Inventory-II
Change in Post-Traumatic Stress Disorder Symptom Checklist for DSM-5 (PCL-5)
Change in State Trait Anxiety Inventory Form Y
Change in Suicide Behavior Questionnaire - Revised (SBQ-R)

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Naturalistic Group
1 of 2
THC Reduction Group
1 of 2
Active Control
Experimental Treatment

215 Total Participants · 2 Treatment Groups

Primary Treatment: THC Reduction Group · No Placebo Group · N/A

THC Reduction Group
Behavioral
Experimental Group · 1 Intervention: Reduce THC Use · Intervention Types: Behavioral
Naturalistic GroupNoIntervention Group · 1 Intervention: Naturalistic Group · Intervention Types:

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, every 2 weeks for 12 weeks, 3, 6, 12 months post baseline

Trial Background

Prof. Leslie Lundahl, Associate Professor
Principal Investigator
Wayne State University
Closest Location: Tolan Park Medical Building · Detroit, MI
Photo of Detroit  1Photo of Detroit  2Photo of Detroit  3
2021First Recorded Clinical Trial
1 TrialsResearching Suicide
5 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 5 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have experienced a traumatic event in the past 6 months that causes you to have persistent anxiety or fear about it.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References