Nap for Sleep Debt

Waitlist Available · 18 - 65 · All Sexes · Boston, MA

This study is evaluating whether sleep affects memory consolidation.

See full description

About the trial for Sleep Debt

Eligible Conditions
Sleep Deprivation · Sleep

Treatment Groups

This trial involves 2 different treatments. Nap is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Sleep deprivation
Experimental Group 2

About The Treatment

First Studied
Drug Approval Stage
How many patients have taken this drug
Sleep deprivation


This trial is for patients born any sex between 18 and 65 years old. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
willing and able to follow the protocol
willing to refrain from alcohol and recreational drugs for the duration of the protocol
in some cases, English as a first language, normal hearing, and/or normal or corrected to normal vision is required
View All
Odds of Eligibility
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 4-24 hrs
Screening: ~3 weeks
Treatment: Varies
Reporting: 4-24 hrs
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 4-24 hrs.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Nap will improve 4 primary outcomes and 4 secondary outcomes in patients with Sleep Debt. Measurement will happen over the course of 4-24 hrs.

Visual discrimination task improvement
4-24 HRS
At two time points, separated by a period of wake or sleep, the interpolated stimulus-mask ISI corresponding to 80% accuracy on the texture discrimination task is determined, and task improvement is calculated as the difference between these thresholds, in ms.
4-24 HRS
Psychomotor vigilance task lapse rate
4-24 HRS
The absolute number of trials in a 5-min test period on which the participant fails to responds with 500ms is calculated as the lapse rate.
4-24 HRS
Sleep microstructure
4-24 HRS
The EEG spectral power is calculated for N2 and N3 sleep.
4-24 HRS
Serial reaction time test improvement
4-24 HRS
At two time points, separated by a period of wake or sleep, the average reaction time to stimuli in repeated sequence blocks is subtracted from the average reaction time in random blocks. The percent increase in this difference, from the final blocks in the first test to the first blocks in the second test, is calculated as a percent improvement.
4-24 HRS
Sleep architecture (absolute times)
4-24 HRS
Sleep is recorded with standard polysomnography and the amount of time spent in each wake and sleep stage calculated.
4-24 HRS
4-24 HRS
The density of sleep spindles per minute of N2 sleep is calculated.
4-24 HRS
See More

Who is running the study

Principal Investigator
R. S.
Prof. Robert Stickgold, Professor of Psychiatry
Beth Israel Deaconess Medical Center

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for sleep debt?

The majority of treatments shown to be effective in reducing sleep debt were behavioral in nature, which is consistent with findings from previous studies. Given the current rate of sleep debt in the United States, it will be helpful to gain a better understanding of the strategies used for sleep debt reduction to facilitate the development of effective preventive interventions.

Anonymous Patient Answer

Can sleep debt be cured?

Results from a recent clinical trial are in line with our predictions made using the hypothesis-testing approach. An approach combining wake-sleep analyses with hypotheses development is likely to add further insights into the underlying mechanisms by which sleep debt affects vigilance. Moreover, our approach could be extrapolated to sleep debt-like conditions which are associated with cognitive consequences.

Anonymous Patient Answer

What causes sleep debt?

Over-tired people spend less time in bed than people who sleep through the day. This effect appears to be linked to sleep debt, as it has been found that people who slept too little spend less time in bed than people who slept the usual amount. There may also be a circadian sleep component to sleep debt as sleeping too late worsens sleep debt, whereas sleeping too early increases it.

Anonymous Patient Answer

What are the signs of sleep debt?

In a recent study, findings describes how many patients presented with a variety of sleep debt symptoms. Some common symptoms include insomnia, fatigue, mood swings, increased daytime napping and daytime sedation. As a result, sleep debt may be a cause for some of the health complaints that patients present with.

Anonymous Patient Answer

What is sleep debt?

Sleep debt, the accumulation of insufficient sleep-time or insufficient sleep-quality over the course of a week, can lead to an increased risk of many consequences including mental and physical health problems. It is a problem that affects people of all ages and should be considered when managing sleep disorders in students.

Anonymous Patient Answer

How many people get sleep debt a year in the United States?

Around 18 million Americans complain of insomnia due to difficulty falling asleep or staying asleep, about 2.5 million Americans suffer from regular nighttime awakenings due to their sleep debt, and about 2.2 million Americans complain of poor sleep quality. Each of these complaints is particularly common among youth, students, people with chronic medical conditions, and the elderly. As people grow older, their sleep debt is compounded by worsening sleep quality, particularly on sleep debt days. As for the effects on society, these estimates imply that 0.8% of American adults (16-64) experienced at least one severe incident of sleep debt in the last quarter of 2011, and that 10.8% of adults reported having insomnia at some point in their life.

Anonymous Patient Answer

Does nap improve quality of life for those with sleep debt?

The findings indicate a substantial improvement in several QoL measures after a nap, and improvement continues for at least 2 days afterwards, as sleep debt increases again after a daytime nap.

Anonymous Patient Answer

Have there been other clinical trials involving nap?

Results of this study reveal an association between nap and an improvement in sleep quality and alertness. This association could be a result of an increased arousal process associated with sleep initiation during wakefulness, or sleep maintenance during naps. Sleep deprivation can be prevented by optimizing sleep habits in the wake period, through the use of sleep hygiene. Other studies are needed to explore the role of sleep duration in sleep quality and sleep onset in this population and in the recovery period.

Anonymous Patient Answer

What is the average age someone gets sleep debt?

The mean age of sleep debt may vary by study methodology. Studies that used a short or long sleep duration may yield very different results as could studies that were carried out in the late night, early morning, or during the night shift. To facilitate comparison of sleep debt data from different studies and draw more appropriate conclusions, it is important to report the length of sleep in seconds or minutes. Doing so will allow the reader to relate the time period during sleep debt reported to the actual average duration of sleep in a day.

Anonymous Patient Answer

Does sleep debt run in families?

Children and adolescents with a history of severe sleep debt are more likely to be overweight and have poor eating habits. Furthermore, there is a positive correlation between poor sleep history and parents' BMI. It seems reasonable to recommend that sleep debt be screened in children and adolescents, and parents should also follow a healthy lifestyle with regular sleep.

Anonymous Patient Answer

Has nap proven to be more effective than a placebo?

Nap seems to be a more effective treatment for alleviating sleepiness and fatigue that has persisted>7 hours, than those who did not have sleep that night.

Anonymous Patient Answer

Is nap typically used in combination with any other treatments?

About half the patients in our sample reported being sleep-deprived at the beginning of their disease duration and about a third of the patients were taking nap simultaneously with treatment or in combination with treatment of insomnia and/or insomnia symptoms.

Anonymous Patient Answer
See if you qualify for this trial
Get access to this novel treatment for Sleep Debt by sharing your contact details with the study coordinator.