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Cognitive Remediation

Cognitive Remediation for Schizophrenia

N/A
Waitlist Available
Research Sponsored by Wesleyan University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
A minimum of 2 months since discharge from last hospitalization.
Meeting DSM-5 criteria for schizophrenia or schizoaffective disorder, presenting for intensive outpatient clinical care.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measures change from study entry, after 3-months of treatment and at a 3-month follow-up.
Awards & highlights

Study Summary

This trial will compare two cognitive remediation programs to help inform best practices for treating cognitive deficits and community function in schizophrenia.

Eligible Conditions
  • Schizophrenia
  • Schizoaffective Disorder

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measures change from study entry, after 3-months of treatment and at a 3-month follow-up.
This trial's timeline: 3 weeks for screening, Varies for treatment, and measures change from study entry, after 3-months of treatment and at a 3-month follow-up. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Matrics Consensus Cognitive Battery score (MCCB composite score)
Quality of Life Scale
UCSD Performance-Based Skills Assessment

Side effects data

From 2013 Phase 3 trial • 120 Patients • NCT01173874
7%
Exacerbation
2%
abnormal ECG
100%
80%
60%
40%
20%
0%
Study treatment Arm
Cognitive Remediation
Cognitive Activity Control Group

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Strategy CR InterventionExperimental Treatment1 Intervention
Participants in this intervention will be treated for 24 hours (2 hours per week, one day per week over 3 months) with Compensatory Cognitive Training (CCT). The therapy targets four cognitive domains: (a) prospective memory, (b) attention and vigilance, (c) learning and memory, and (d) executive function. The program is a group-based intervention that teaches strategies via interactive, game-like activities to maintain interest and enhance motivation and engagement.
Group II: Restorative CR InterventionExperimental Treatment1 Intervention
The restorative remediation intervention will consist of a target of 50 hours (5 hours per week, 1 hour per day, over 3 months) of a sequence of computerized cognitive exercises designed to improve cognitive function through repeated drill-and-practice of exercises largely focused on attention, working memory and verbal episodic memory. Cognitive deficits will be directly targeted by these exercises. Exercises will be started at individually determined levels of difficulty at which each client will be successful, e.g., 80% accuracy. Task difficulty will be increased as performance improves.
Group III: Computer GamesPlacebo Group1 Intervention
Three months of 1-hour, 5-times per week, client-selected computer games.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive Remediation
2010
Completed Phase 3
~1790

Find a Location

Who is running the clinical trial?

Wesleyan UniversityLead Sponsor
2 Previous Clinical Trials
330 Total Patients Enrolled
Hartford HospitalOTHER
132 Previous Clinical Trials
18,787 Total Patients Enrolled
3 Trials studying Schizophrenia
651 Patients Enrolled for Schizophrenia
National Institute of Mental Health (NIMH)NIH
2,774 Previous Clinical Trials
2,674,168 Total Patients Enrolled
247 Trials studying Schizophrenia
89,295 Patients Enrolled for Schizophrenia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~25 spots leftby Mar 2025