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Molecular-Guided Therapy for Childhood Cancer
Study Summary
This trial is testing if new technology that decodes a tumor's DNA can help docs better understand cancer & predict treatment.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I do not have any serious infections or life-threatening illnesses unrelated to my cancer.My liver functions within normal limits.My child's cancer cannot be cured with known treatments or has not responded to standard therapies.My cancer can be seen and measured on scans, and it's possible to take a biopsy.My white blood cell count is high enough to start treatment.My brain condition is stable, and I haven't needed more medicine for it in the last 2 weeks.I haven't had radiation on the primary cancer site in the last 2 weeks.I can do most activities but need help with some.I haven't had chemotherapy in the week before my biopsy.I am older than 12 months.I was 21 years old or younger when first diagnosed.I am a woman capable of becoming pregnant and have a negative pregnancy test.I agree to use effective birth control during and 6 months after treatment.My condition has no known effective treatment.
- Group 1: Guided Therapy
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Frequently Asked Questions
Is it currently possible to join this research endeavor?
"Based on the information provided by clinicaltrials.gov, this experiment is not currently enrolling candidates. Despite first being posted June 1st 2014 and last edited April 20th 2022, no patient are presently being recruited for this trial but there are 1253 other studies that require volunteers at present."
Who is able to sign up for the experiment?
"This clinical trial is recruiting 184 participants with clear cell sarcoma of soft tissue in the age range of 13 Months - 21. To be eligible, individuals must have been diagnosed with Medulloblastomas (At relapse after accepted curative therapy), Ependymomas (At relapse following standard care or non-responsive/progressive to treatment), Brain Tumors and Neuroblastoma (Post high risk therapy relapsed patients or MYCN amplified patient over 15 months old). Candidates shall also need to fulfill other criteria including post-standard chemotherapy progression or lack of efficacy for accepted treatments."
Is the upper age limit for recruitment into this trial lower than 85 years?
"Subjects aged between 13 Months and 21 years are currently being sought for this trial."
Where are the venues wherein this clinical experiment is taking place?
"As part of this medical trial, patients can be enrolled at Penn State Milton S. Hershey Medical Center and Children's Hospital in Hershey, Pennsylvania, Helen DeVos Children's Hospital in Grand Rapids, Michigan and Connecticut Children's Hospital in Hartford as well as 18 other sites nationwide."
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