Treatment for Cytomegalovirus Retinitis

Phase-Based Progress Estimates
Foscarnet Research Program / Park Plaza Hosp, Houston, TX
Cytomegalovirus Retinitis+4 More
All Sexes
What conditions do you have?

Study Summary

This study is evaluating whether a drug called foscarnet can be used to treat cytomegalovirus retinitis in people with AIDS.

See full description

Eligible Conditions

  • Cytomegalovirus Retinitis
  • HIV Infections

Treatment Effectiveness

Effectiveness Progress

1 of 3

Trial Safety

Safety Progress

1 of 3

Trial Design

0 Treatment Group

This trial involves 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 5 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly up to 5 years for reporting.

Closest Location

Foscarnet Research Program / Park Plaza Hosp - Houston, TX

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:

Patient Q&A Section

What is retinitis?

"Retinitis is a disease that affects an eye's optic nerve and retinal tissue or light-sensitive outer layer of the retina. It is caused by inflammation of the intraretinal tissues of the eye. It is characterized by an eye lesion, inflammation and scar formation.\n" - Anonymous Online Contributor

Unverified Answer

Can retinitis be cured?

"Patients that do have a response to standard therapy with high dose topical cyclosporin A can be cured with steroid-sparing and combination medical therapy. Even though this is a retrospective study with no randomization. This is an indication that treatment with drugs like Prednisone or Triamcinolone acetonide can be considered for the management of severe retinitis, in cases that would not justify using cyclosporin A. A randomized controlled trial would be of paramount importance to confirm this." - Anonymous Online Contributor

Unverified Answer

How many people get retinitis a year in the United States?

"Although there were some inconsistencies among sources of data, it is believed that the observed prevalence rate of U.S. retinitis is at least as high as that found in Europe and the UK. There appears to be no clear seasonal variation in the incidence of disease, despite the presence of a significant proportion of the cases occurring in the Northern Hemisphere." - Anonymous Online Contributor

Unverified Answer

What are common treatments for retinitis?

"Common treatments for retinitis are primarily limited to intravitreal injections of drugs. Other treatments include laser photocoagulation and cryotherapy. Laser and cryotherapy are usually effective when combined with intravitreal injections, while intravitreal injections, without treatment, are rarely repeated." - Anonymous Online Contributor

Unverified Answer

What are the signs of retinitis?

"Some changes of the eye include blurred vision and detachment of the eyelashes or eyelid. Many more signs include blindness and swelling of the face. These can all potentially lead to referral to ophthalmologists (eye doctors) as the symptoms could be from any of many diseases.\n\n- - BBC News: 'No sign baby death link'\n\n- - NCBI: Schizophrenia\n- www.nhs." - Anonymous Online Contributor

Unverified Answer

What causes retinitis?

"Retinitis can occur in the setting of any disease that causes the eye to become inflamed. Although retinitis can be a cause of blindness, it is most frequently the result of the disease itself.\n\nOphthalmic diseases are those disorders of the eye and/or its surrounding structures.\n\nA new field of ophthalmology is that of ocular prosthesis, which is a new type of surgical or prosthetic eye.\n\nAn eye proschestomy (Latin for creation of a new eye) is the process of forming a new eye from a patient's existing eye. This may be done as part of eye reconstruction in cases such as ocular trauma." - Anonymous Online Contributor

Unverified Answer

Is treatment safe for people?

"Despite their poor prognosis, most of the treatment effects found in people with aHUS had a positive effect on at least one of the patients involved, and had to be tolerated very well. There is a need to investigate additional strategies to treat people with aHUS, such as aHUS variants. There are indications that the number of cases could be rising. This should lead to preventive action against aHUS and the related diseases." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in treatment for therapeutic use?

"We have witnessed an exponential growth in the number of new drugs and the number of therapies coming into use. Although the FDA approves all drugs regardless of their safety, many new treatments are still in development. Even though we know more about how drugs work and how treatments are made, we continue to work on new ones that may be needed to treat those patients who suffer from debilitating diseases such as diabetes." - Anonymous Online Contributor

Unverified Answer

Has treatment proven to be more effective than a placebo?

"The outcome from patients treated using the combination ointment as a treatment for the eyes, eyesight, and inflammation was more effective than that of patients receiving a placebo. In a recent study, findings of the current study suggest that the combination ointment is efficacious against the inflammation of the eyes and improvement in eye sight and treatment is also supported by the results of the visual test." - Anonymous Online Contributor

Unverified Answer

What is treatment?

"The most well-supported treatment option for dry macular degeneration is intravitreal injections of pegaptanib (sold under the name "Lucentis") for a short time. It is generally considered as a treatment option for people who have previously received surgery but are not comfortable undergoing the surgery for other reasons. The benefits of pegaptanib have been shown in a double-sized study. Treatment of nystagmus with a bifocally-tipped prism was effective in improving fixation in patients with amblyopia." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving treatment?

"The most commonly used treatment methods for diabetic macular degeneration and diabetic retinopathy have not been tested for safety in diabetic patients in clinical research settings." - Anonymous Online Contributor

Unverified Answer

How does treatment work?

"Overall results showed a correlation between retinopathy severity and vision-threatening complications of neovascular retinopathy. Patients with a neovascular-affected macula were more likely to require treatment in order to preserve vision." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Cytomegalovirus Retinitis by sharing your contact details with the study coordinator.