← Back to Search

N-methyl-D-aspartate (NMDA) receptor antagonist

Subanesthetic ketamine for Mechanical Ventilation

N/A
Waitlist Available
Led By Lorenzo Berra, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Suitable for spontaneous breathing trial
Candidate to received low dose ketamine by the primary critical care team
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured 15 minutes prior to initiation of ketamine infusion, at 60 minutes of ketamine infusion at 5mcg/kg/min, at another 60 minutes of infusion at 10mcg/kg/min, and at 2 hours after stopping the infusion
Awards & highlights

Study Summary

This trial is testing whether ketamine can help keep people on a ventilator by improving their breathing and reducing the amount of opioids and propofol needed.

Eligible Conditions
  • Mechanical Ventilation
  • Airway Obstruction
  • Respiratory Depression

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are able to breathe on your own without the need for assistance.
Select...
The primary critical care team has recommended that you receive a low dose of ketamine.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured 15 minutes prior to initiation of ketamine infusion, at 60 minutes of ketamine infusion at 5mcg/kg/min, at another 60 minutes of infusion at 10mcg/kg/min, and at 2 hours after stopping the infusion
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured 15 minutes prior to initiation of ketamine infusion, at 60 minutes of ketamine infusion at 5mcg/kg/min, at another 60 minutes of infusion at 10mcg/kg/min, and at 2 hours after stopping the infusion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in duty cycle
Change in minute ventilation
Change in peak inspiratory flow
+2 more
Secondary outcome measures
Changes in power spectrum densities
Changes in volumetric capnography
Confusion Assessment Measurement for the ICU (CAM-ICU)
+6 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: CohortExperimental Treatment1 Intervention
Adult mechanically ventilated patients who are deemed eligible for a spontaneous breathing trial and are candidates to receive subanesthetic ketamine by the primary critical care team.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ketamine
FDA approved

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,918 Previous Clinical Trials
13,192,820 Total Patients Enrolled
Beth Israel Deaconess Medical CenterOTHER
835 Previous Clinical Trials
13,006,515 Total Patients Enrolled
Lorenzo Berra, MDPrincipal InvestigatorMassachusetts General Hospital
16 Previous Clinical Trials
819 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the primary objective of this clinical experiment?

"This trial's primary aim is to evaluate the effect of ketamine on tidal volume, and secondary outcomes include confusion assessment measurement for the ICU (CAM-ICU), oxygen blood saturation as measured by pulse oximetry, and number of days mechanically ventilated. Data points will be recorded 15 minutes before ketamine infusion begins, at 60 minute intervals during 5mcg/kg/min and 10mcg/kg/min infusions respectively, then again two hours after stoppingthe infusion."

Answered by AI

How many individuals are involved in this research endeavor?

"This clinical trial has already closed recruitment and was last modified on November 8th 2022. That said, there are still 209 studies recruiting for mechanical ventilation treatments and 105 trials looking to enroll subjects that plan to use subanesthetic ketamine."

Answered by AI

Are there any opportunities for prospective participants to join this experiment?

"This medical experiment is no longer registering participants. It was initially posted on January 1st 2014, with the latest update occurring on November 8th 2022. For those searching for similar studies, 209 clinical trials are currently recruiting patients requiring ventilation and 105 studies examining subanesthetic ketamine's therapeutic potential are actively enrolling subjects."

Answered by AI
Recent research and studies
~1 spots leftby Mar 2025