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Cell Therapy

Decidual Stromal Cells (DSC) for COVID-19

N/A
Waitlist Available
Led By John Granton, M.D.
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Receiving mechanical ventilation
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 180 days
Awards & highlights

Study Summary

This trial will test how safe and effective decidual stromal cells are in treating patients with respiratory failure caused by COVID-19.

Eligible Conditions
  • COVID-19
  • Coronavirus
  • Acute Respiratory Distress Syndrome

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are currently on a machine to help you breathe.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~180 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 180 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of ventilator free days following infusion of decidual stromal cells
Secondary outcome measures
All-cause morality rate
Average days not requiring vasopressors
Average number of day without supplemental oxygen
+7 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Decidual Stromal Cells (DSC)Experimental Treatment1 Intervention
Participants will receive one dose of DSC at 1x10^6/kg. A second dose may be given sometime between Day 5 and Day 8 if the participant's condition improves.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Decidual Stromal Cells (DSC)
2020
N/A
~20

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,456 Previous Clinical Trials
482,780 Total Patients Enrolled
27 Trials studying COVID-19
113,375 Patients Enrolled for COVID-19
Oslo University HospitalOTHER
1,068 Previous Clinical Trials
1,294,216 Total Patients Enrolled
14 Trials studying COVID-19
55,336 Patients Enrolled for COVID-19
John Granton, M.D.Principal InvestigatorToronto General Hospital
1 Previous Clinical Trials
150 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research the inaugural venture into its experimental field?

"Decidual Stromal Cells (DSC) have been researched since 2018, when the initial trial was sponsored by Pluristem Ltd. After completing the first study of 240 patients in that year, this medication achieved Phase 3 approval and is now present in 6 different cities across 6 nations with three active trials ongoing."

Answered by AI

Does this study permit individuals younger than 60 years to participate?

"Eligible participants must be above the age of legal majority and under 75 years old."

Answered by AI

Are there any preceding experiments that have utilized Decidual Stromal Cells (DSC)?

"Presently, three trials exploring Decidual Stromal Cells (DSC) are taking place. One is currently in its final phase of clinical research. While the majority of studies for this treatment take place Kfar-Saba, 21 other locations across the US have initiated their own investigations into DSC efficacy."

Answered by AI

Who is eligible for enrollment into this medical research?

"This research is looking to enlist 19 individuals, aged 18-75 years old, who have been afflicted with the SARS-CoV-2 virus. Other prerequisites include ARDS not caused by a heart concern, ability to provide consent or an LAR can do so on their behalf and receiving mechanical ventilation."

Answered by AI

How many individuals have been accepted to participate in this research?

"Unfortunately, no new patients are being accepted for this trial at the present time. Initially posted on September 25th 2020 and most recently updated on May 9th 2022, other potential studies may be of interest such as 1334 trials with active recruitment related to Covid-19 or 3 studies focused on Decidual Stromal Cells (DSC)."

Answered by AI

Are new participants being accepted for this research effort?

"At present, this research is not accepting subjects. It was first announced on September 25th 2020 and its information was most recently revised on May 9th 2022. For those looking for other trials, there are currently 1334 studies actively seeking participants with COVID-19 as well as 3 DSC clinical experiments that are open to recruitment."

Answered by AI
~4 spots leftby Mar 2025