HFNC flow set at 2 times of patient peak tidal inspiratory flow for Hypoxemic Respiratory Failure

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Hypoxemic Respiratory FailureHFNC flow set at 2 times of patient peak tidal inspiratory flow - Other
Eligibility
18 - 90
All Sexes
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Study Summary

This trial is exploring the correlation between a patient's peak tidal inspiratory flow pre and post extubation, as well as their response to different high-flow nasal cannula flows.

Eligible Conditions
  • Hypoxemic Respiratory Failure

Treatment Effectiveness

Study Objectives

1 Primary · 2 Secondary · Reporting Duration: 20 minutes after each flow setting

20 minutes after each flow setting
End-expiratory lung volume assessed by EIT
SpO2/FIO2
self-evaluated comfort

Trial Safety

Trial Design

4 Treatment Groups

HFNC flow set at patient peak tidal inspiratory flow
1 of 4
HFNC flow set at 2 times of patient peak tidal inspiratory flow
1 of 4
HFNC flow set at 1.67 times of patient peak tidal inspiratory flow
1 of 4
HFNC flow set at 1.33 times of patient peak tidal inspiratory flow
1 of 4

Active Control

Experimental Treatment

28 Total Participants · 4 Treatment Groups

Primary Treatment: HFNC flow set at 2 times of patient peak tidal inspiratory flow · No Placebo Group · N/A

HFNC flow set at 2 times of patient peak tidal inspiratory flow
Other
Experimental Group · 1 Intervention: HFNC flow set at 2 times of patient peak tidal inspiratory flow · Intervention Types: Other
HFNC flow set at 1.67 times of patient peak tidal inspiratory flow
Other
Experimental Group · 1 Intervention: HFNC flow set at 1.67 times of patient peak tidal inspiratory flow · Intervention Types: Other
HFNC flow set at 1.33 times of patient peak tidal inspiratory flow
Other
Experimental Group · 1 Intervention: HFNC flow set at 1.33 times of patient peak tidal inspiratory flow · Intervention Types: Other
HFNC flow set at patient peak tidal inspiratory flow
Other
ActiveComparator Group · 1 Intervention: HFNC flow set at patient peak tidal inspiratory flow · Intervention Types: Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 20 minutes after each flow setting

Who is running the clinical trial?

Hospital Vall d'HebronOTHER
74 Previous Clinical Trials
60,109 Total Patients Enrolled
Rush University Medical CenterLead Sponsor
390 Previous Clinical Trials
153,506 Total Patients Enrolled
Jie Li, PhDPrincipal InvestigatorRush University
9 Previous Clinical Trials
408 Total Patients Enrolled

Eligibility Criteria

Age 18 - 90 · All Participants · 3 Total Inclusion Criteria

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References