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HFNC flow set at 2 times of patient peak tidal inspiratory flow for Hypoxemic Respiratory Failure

N/A
Waitlist Available
Led By Jie Li, PhD
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Have at least one of the indications to use HFNC after extubation
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 20 minutes after each flow setting
Awards & highlights

Study Summary

This trial is exploring the correlation between a patient's peak tidal inspiratory flow pre and post extubation, as well as their response to different high-flow nasal cannula flows.

Eligible Conditions
  • Hypoxemic Respiratory Failure

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You need high flow nasal cannula (HFNC) treatment after being taken off a breathing tube.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~20 minutes after each flow setting
This trial's timeline: 3 weeks for screening, Varies for treatment, and 20 minutes after each flow setting for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
SpO2/FIO2
Secondary outcome measures
End-expiratory lung volume assessed by EIT
self-evaluated comfort

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: HFNC flow set at 2 times of patient peak tidal inspiratory flowExperimental Treatment1 Intervention
HFNC flow will be set at the level that is 2 times of patient peak tidal inspiratory flow
Group II: HFNC flow set at 1.67 times of patient peak tidal inspiratory flowExperimental Treatment1 Intervention
HFNC flow will be set at the level that is 1.67 times of patient peak tidal inspiratory flow
Group III: HFNC flow set at 1.33 times of patient peak tidal inspiratory flowExperimental Treatment1 Intervention
HFNC flow will be set at the level that is 1.33 times of patient peak tidal inspiratory flow
Group IV: HFNC flow set at patient peak tidal inspiratory flowActive Control1 Intervention
HFNC flow will be set at the level that matches patient peak tidal inspiratory flow

Find a Location

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
418 Previous Clinical Trials
162,494 Total Patients Enrolled
Hospital Vall d'HebronOTHER
85 Previous Clinical Trials
64,650 Total Patients Enrolled
Jie Li, PhDPrincipal InvestigatorRush University
9 Previous Clinical Trials
408 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still opportunities for people to get involved in the research?

"Clinicaltrials.gov information presents the trial as actively recruiting participants, with an initial postdate of April 7th 2022 and a last revision on October 28th 2022."

Answered by AI

Does the research have any age restrictions, such as prohibiting those younger than 45 years old?

"This clinical trial has set the minimum age of enrolment at 18, while those over 90 years old are excluded from participating."

Answered by AI

How many participants are in the current experiment?

"Affirmative - the information provided by clinicaltrials.gov suggests that this study is currently recruiting patients; it was posted on April 7th 2022 and last changed October 28th 2022. In total, the trial intends to enrol 28 individuals from a single site."

Answered by AI

For what demographic is enrollment in this investigation most suitable?

"To meet the eligibility requirements of this study, participants must have suffered from anoxia and be aged between 18 to 90 years old. This trial seeks 28 enrollees in total."

Answered by AI
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~2 spots leftby Mar 2025