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Respiratory Support
Positive end-expiratory pressure (PEEP) for Obesity
N/A
Waitlist Available
Led By Lorenzo Berra, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
A well functioning arterial line.
Intubated and mechanically ventilated;
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 hours
Awards & highlights
Study Summary
This trial is testing whether a certain level of PEEP ("Titrated-PEEP") increases the likelihood of successful ventilator liberation in obese patients.
Eligible Conditions
- Obesity
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 24 hours
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 hours
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Differences in WOB at titrated PEEP levels vs. ZEEP level
Secondary outcome measures
Gas Exchange - Arterial carbon dioxide
Gas Exchange - Oxygenation
Gas Volume Distribution
+3 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Patients with BMI > 35Experimental Treatment2 Interventions
ICU patients with a BMI > 35, on pressure support ventilation, scheduled for spontaneous breathing trial for evaluation of extubation
After recruitment maneuver and decremental PEEP trial, the "Titrated-PEEP" is identified. Patients will have two spontaneous breathing trials (SBTs) in randomized order. Either the patient will receive SBT at PEEP = 0-5 cmH2O, with PSV=0 and FiO2 unchanged; or the patient will perform an SBT at "Titrated-PEEP", with the PSV=0 and FiO2 unchanged.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
ZEEP
2017
N/A
~150
Find a Location
Who is running the clinical trial?
Massachusetts General HospitalLead Sponsor
2,923 Previous Clinical Trials
13,193,354 Total Patients Enrolled
70 Trials studying Obesity
290,852 Patients Enrolled for Obesity
Lorenzo Berra, MDPrincipal InvestigatorMassachusetts General Hospital
16 Previous Clinical Trials
795 Total Patients Enrolled
2 Trials studying Obesity
56 Patients Enrolled for Obesity
Robert Kacmarek, RRT, PhDPrincipal InvestigatorMassachusetts General Hospital
3 Previous Clinical Trials
106 Total Patients Enrolled
2 Trials studying Obesity
56 Patients Enrolled for Obesity
Frequently Asked Questions
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