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Respiratory Support

Positive end-expiratory pressure (PEEP) for Obesity

N/A
Waitlist Available
Led By Lorenzo Berra, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
A well functioning arterial line.
Intubated and mechanically ventilated;
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 hours
Awards & highlights

Study Summary

This trial is testing whether a certain level of PEEP ("Titrated-PEEP") increases the likelihood of successful ventilator liberation in obese patients.

Eligible Conditions
  • Obesity

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Differences in WOB at titrated PEEP levels vs. ZEEP level
Secondary outcome measures
Gas Exchange - Arterial carbon dioxide
Gas Exchange - Oxygenation
Gas Volume Distribution
+3 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients with BMI > 35Experimental Treatment2 Interventions
ICU patients with a BMI > 35, on pressure support ventilation, scheduled for spontaneous breathing trial for evaluation of extubation After recruitment maneuver and decremental PEEP trial, the "Titrated-PEEP" is identified. Patients will have two spontaneous breathing trials (SBTs) in randomized order. Either the patient will receive SBT at PEEP = 0-5 cmH2O, with PSV=0 and FiO2 unchanged; or the patient will perform an SBT at "Titrated-PEEP", with the PSV=0 and FiO2 unchanged.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
ZEEP
2017
N/A
~150

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,923 Previous Clinical Trials
13,193,354 Total Patients Enrolled
70 Trials studying Obesity
290,852 Patients Enrolled for Obesity
Lorenzo Berra, MDPrincipal InvestigatorMassachusetts General Hospital
16 Previous Clinical Trials
795 Total Patients Enrolled
2 Trials studying Obesity
56 Patients Enrolled for Obesity
Robert Kacmarek, RRT, PhDPrincipal InvestigatorMassachusetts General Hospital
3 Previous Clinical Trials
106 Total Patients Enrolled
2 Trials studying Obesity
56 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~4 spots leftby Mar 2025