← Back to Search

Bariatric Surgery + Medical Management of CKD. for Obesity (BARICADE Trial)

N/A
Waitlist Available
Led By Dennis Hong, MD MSc FRCSC
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up month 18
Awards & highlights

BARICADE Trial Summary

This trial will test whether bariatric surgery can help reduce the progression of chronic kidney disease (CKD) in obese patients. If successful, the results could lead to this surgery becoming a treatment option for CKD.

Eligible Conditions
  • Obesity
  • Post-Gastric Bypass Surgery
  • Chronic Kidney Disease

BARICADE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~month 18
This trial's timeline: 3 weeks for screening, Varies for treatment, and month 18 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Creatine Clearance (units: mL/min) at 12 months
Creatine Clearance (units: mL/min) at 18 months
Creatine Clearance (units: mL/min) at 6 months
+15 more
Secondary outcome measures
Crossover rate between control and intervention arm
Intervention Administration Rate
Number of patients adhering to study treatments
+4 more

BARICADE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Bariatric Surgery + Medical Management for Chronic Kidney DiseaseExperimental Treatment1 Intervention
The intervention group will include medical management and bariatric surgery, which will consist of Roux-en-Y gastric bypass or sleeve gastrectomy performed according to local practice standards. Medical management for CKD will be directed by nephrologists at St. Joseph's Healthcare Hamilton. Comorbidities such as hypertension, dyslipidemia, and type 2 diabetes will be managed at the discretion of individual nephrologists. Generally, this can include anti-hypertensives (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) for systolic blood pressure control below a target of <140/90 mmHg (<130/80 in patients with type 2 diabetes), statins in patients with dyslipidemia to target low-density lipoprotein <2mmol/L for the treatment of CKD.
Group II: Medical Management for Chronic Kidney DiseaseActive Control1 Intervention
Medical management for CKD will be directed by nephrologists at St. Joseph's Healthcare Hamilton. Comorbidities such as hypertension, dyslipidemia, and type 2 diabetes will be managed at the discretion of individual nephrologists. Generally, this can include anti-hypertensives (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) for systolic blood pressure control below a target of <140/90 mmHg (<130/80 in patients with type 2 diabetes), statins in patients with dyslipidemia to target low-density lipoprotein <2mmol/L for the treatment of CKD.

Find a Location

Who is running the clinical trial?

McMaster Surgical AssociatesOTHER
16 Previous Clinical Trials
46,459 Total Patients Enrolled
American College of SurgeonsOTHER
15 Previous Clinical Trials
60,149 Total Patients Enrolled
McMaster UniversityLead Sponsor
876 Previous Clinical Trials
2,595,940 Total Patients Enrolled
15 Trials studying Obesity
1,312 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this medical trial accessible to individuals under the age of 75?

"This medical trial necessitates that applicants are between 18 and 70 years old. There is an abundance of trials available for those younger than 18 (253) or older than 65 (1162)."

Answered by AI

Does the research team have openings for enrollees yet?

"This clinical trial, as indicated on clinicaltrials.gov, is not currently recruiting patients. Initially posted April 1st 2022 and last updated February 13th 2022, the study has been suspended from recruitment; however there are still 1566 other trials accepting participants at this moment in time."

Answered by AI

Which individuals are eligible to partake in this medical research?

"The prerequisites for this clinical trial are a BMI greater than 30 and between 18-70 years of age. Sixty people must be recruited in total to participate."

Answered by AI
Recent research and studies
~21 spots leftby Mar 2025