Impact Load Exercises for Relative Energy Deficiency in Sport

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Virginia Polytechnic Institute and State University, Blacksburg, VA
Relative Energy Deficiency in Sport+1 More
Impact Load Exercises - Behavioral
Eligibility
18 - 65
Female
What conditions do you have?
Select

Study Summary

This study is a randomized, cross-over intervention study that will evaluate the effect of brief, high-impact loading exercises on biomarkers of bone metabolism in energy-restricted, eumenorrheic female runners. Volunteers will complete two, 5-day experimental conditions in a randomized order separated by one menstrual cycle (approximately 3 weeks). Experimental conditions will include a dietary intervention of energy intake equal to 30 kcal/kg of fat-free mass/d using controlled diets and an exercise intervention of daily treadmill running with or without an additional 50 impact loading exercises.

Eligible Conditions

  • Relative Energy Deficiency in Sport

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Relative Energy Deficiency in Sport

Study Objectives

7 Primary · 2 Secondary · Reporting Duration: 10-minute blood draw in laboratory; lab service samples analyzed within 24 hours; other assays completed at end of study

1-minute measurement in laboratory
Change in Body Weight
10-minute blood draw in laboratory; assays completed at end of study
Change in Blood Biomarkers of Bone Remodeling
Hour 24
Change in Blood Hormone and Metabolic Markers
Day 6
Change in Blood Metabolic Marker - Insulin-like Growth Factor-1
Change in Blood Metabolic Marker - Parathyroid hormone
Change in Bone Remodeling Biomarker - C-terminal telopeptide of type 1 collagen
Change in Bone Remodeling Biomarker - N-terminal propeptide of type 1 procollagen
12-minute measurement in laboratory
Change in Running Economy
Continuous collection for 5 consecutive days during each intervention
Change in 24-hour Glucose Patterns

Trial Safety

Safety Progress

1 of 3

Other trials for Relative Energy Deficiency in Sport

Trial Design

2 Treatment Groups

Endurance Exercise Only
1 of 2
Endurance and Jumping Exercises
1 of 2
Active Control
Experimental Treatment

15 Total Participants · 2 Treatment Groups

Primary Treatment: Impact Load Exercises · No Placebo Group · N/A

Endurance and Jumping Exercises
Behavioral
Experimental Group · 1 Intervention: Impact Load Exercises · Intervention Types: Behavioral
Endurance Exercise Only
Behavioral
ActiveComparator Group · 1 Intervention: No Impact Load Exercises · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 10-minute blood draw in laboratory; lab service samples analyzed within 24 hours; other assays completed at end of study
Closest Location: Virginia Polytechnic Institute and State University · Blacksburg, VA
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2011First Recorded Clinical Trial
1 TrialsResearching Relative Energy Deficiency in Sport
5 CompletedClinical Trials

Who is running the clinical trial?

Virginia Polytechnic Institute and State UniversityLead Sponsor
108 Previous Clinical Trials
25,519 Total Patients Enrolled
Enette Larson-Meyer, PhDPrincipal InvestigatorVirginia Polytechnic Institute and State University (Virginia Tech)
1 Previous Clinical Trials
32 Total Patients Enrolled

Eligibility Criteria

Age 18 - 65 · Female Participants · 6 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You run at least 30 miles per week, at least 5 days per week.
You are willing to consume provided meals and snacks.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.