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Novelty facilitated extinction for Anxiety Disorders

N/A
Waitlist Available
Research Sponsored by University of Texas at Austin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Male or female volunteer aged 18-50 years old
Able to understand procedures and agree to participate in the study by giving written informed consent.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up only on the day of the experiment
Awards & highlights

Study Summary

The purpose of this study is to use functional magnetic resonance imaging to investigate how the human brain learns to form associations between neutral and emotional stimuli. The study is based on the basic principles of Pavlovian conditioning. When someone learns that a neutral stimulus (such as the sound of a bell) predicts an unpleasant stimulus (such as a mild electrical shock), the neutral stimulus takes on the properties of an emotional stimulus. The investigators are interested in the neural processes involved in this learning in people with a clinical anxiety disorder and posttraumatic stress disorder (PTSD).

Eligible Conditions
  • Anxiety Disorders
  • Post-Traumatic Stress Disorder
  • Social Anxiety Disorder
  • Panic Disorder

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~only on the day of the experiment
This trial's timeline: 3 weeks for screening, Varies for treatment, and only on the day of the experiment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in functional magnetic resonance imaging (fMRI)-BOLD (blood-oxygen-level dependent) signal in sensory, prefrontal, and limbic regions during a study on the neurobiology of Pavlovian fear conditioning in humans
Secondary outcome measures
Skin conductance responses evoked during a Pavlovian fear conditioning task in humans as an index of physiological arousal.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Standard extinctionExperimental Treatment1 Intervention
The shock is omitted during standard extinction
Group II: Novelty facilitated extinctionExperimental Treatment1 Intervention
Behavioral intervention. After Pavlovian fear conditioning, the shock is omitted and replaced by a novel, surprising, and neutral auditory tone.

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Who is running the clinical trial?

University of Texas at AustinLead Sponsor
347 Previous Clinical Trials
80,272 Total Patients Enrolled
17 Trials studying Anxiety Disorders
2,579 Patients Enrolled for Anxiety Disorders

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~5 spots leftby Mar 2025