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Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose for Obesity

N/A
Waitlist Available
Research Sponsored by Virginia Polytechnic Institute and State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
BMI between 18.5-40 kg/m2
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30-minute measurement
Awards & highlights

Study Summary

This trial is testing whether differences in reinforcement learning/flavor-nutrient conditioning of carbohydrate can be measured across the body mass index range, and whether there is a relationship between metabolic flexibility and calorie-predictive reward.

Eligible Conditions
  • Overweight and Obesity

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
Your body mass index (BMI) falls between 18.5 and 40 kg/m2.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30-minute measurement
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30-minute measurement for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in preference- liking
Secondary outcome measures
Blood glucose response to beverages
Blood insulin response to beverages
Oxygen saturation measurement
+5 more

Trial Design

4Treatment groups
Experimental Treatment
Group I: Conditioned Stimulus- (CS-) and High Fat Test Meal FirstExperimental Treatment4 Interventions
Participants will undergo exposure sessions with flavored beverage solutions containing sucralose first. They will also undergo the high fat meal test session inside the metabolic chamber first. Then, they will undergo exposure sessions with flavored beverages containing sucrose and the high carbohydrate test meal session.
Group II: Conditioned Stimulus- (CS-) and High Carbohydrate Test Meal FirstExperimental Treatment4 Interventions
Participants will undergo exposure sessions with flavored beverage solutions containing sucralose first. They will also undergo the high carbohydrate meal test session inside the metabolic chamber first. Then, they will undergo exposure sessions with flavored beverages containing sucrose and the high fat test meal session.
Group III: Conditioned Stimulus+ (CS+) and High Fat Test Meal FirstExperimental Treatment4 Interventions
Participants will undergo exposure sessions with flavored beverage solutions containing sucrose first. They will also undergo the high fat meal test session inside the metabolic chamber first. Then, they will undergo exposure sessions with flavored beverages containing sucralose and the high carbohydrate test meal session.
Group IV: Conditioned Stimulus+ (CS+) and High Carbohydrate Test Meal FirstExperimental Treatment4 Interventions
Participants will undergo exposure sessions with flavored beverage solutions containing sucrose first. They will also undergo the high carbohydrate meal test session inside the metabolic chamber first. Then, they will undergo exposure sessions with flavored beverages containing sucralose and the high fat test meal session.

Find a Location

Who is running the clinical trial?

Virginia Polytechnic Institute and State UniversityLead Sponsor
139 Previous Clinical Trials
27,672 Total Patients Enrolled
9 Trials studying Obesity
4,215 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still openings available for prospective participants in this study?

"The details published on clinicaltrials.gov demonstrate that this trial is actively seeking participants, which it has been doing since February 23rd 2022. The information was last revised on November 17th of the same year."

Answered by AI

What is the total sample size included in this clinical investigation?

"Yes, as indicated on clinicaltrials.gov information portal, this experiment is currently in need of participants. It was initially put up for public notice on 23rd February 2022 and later modified on November 17th that year. 15 individuals are expected to be enrolled from just one site."

Answered by AI

Does this research embrace participants aged 35 and up?

"To be eligible to partake in this medical trial, patients must between 18-45 years of age. For those below the required range, there are 54 trials available while 206 studies exist for those above 65."

Answered by AI

Is my profile suitable for participation in this study?

"This biomedical trial is seeking 15 adults between 18-45 years of age with obesity. In addition, participants must have a BMI within the range of 18.5 to 40 kg/m2, not be pregnant or intending on becoming so during the study period, live in or near Roanoke and be able speak English fluently; for those receiving fMRI scans only, their BMIs should fall between 25-35 kg/m2."

Answered by AI
~6 spots leftby Mar 2025