CLINICAL TRIAL

Cardiovascular exercise training for Diabetes Mellitus, Type 2

Recruiting · 18 - 65 · All Sexes · Aurora, CO

Cardiovascular Mechanisms of Exercise Intolerance in Diabetes and the Role of Sex

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About the trial for Diabetes Mellitus, Type 2

Eligible Conditions
Diabetes Mellitus · Overweight · Type 2 Diabetes Mellitus · Healthy Subjects (HS) · Cardiovascular Risk · Diabetes Mellitus, Type 2

Treatment Groups

This trial involves 2 different treatments. Cardiovascular Exercise Training is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Cardiovascular exercise training
OTHER
Experimental Group 2
Cardiovascular exercise training
OTHER

Eligibility

This trial is for patients born any sex between 18 and 65 years old. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Sedentary subjects not participating in a regular exercise program (<one bout of exercise/week)
Men and women with and without type 2 diabetes
BMI 25-40
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Through study completion, approximately 4 months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Through study completion, approximately 4 months.
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Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Cardiovascular exercise training will improve 3 primary outcomes in patients with Diabetes Mellitus, Type 2. Measurement will happen over the course of Through study completion, approximately 4 months.

Change in muscular mitochondrial function
THROUGH STUDY COMPLETION, APPROXIMATELY 4 MONTHS
The investigators will examine mitochondrial function using magnetic resistance (MR) spectroscopy during single leg calf exercise
Change in peak oxygen consumption (VO2peak)
THROUGH STUDY COMPLETION, APPROXIMATELY 4 MONTHS
Subjects' peak oxygen consumption will be tested on a stationary bike before and after 3 months of exercise
Change in insulin sensitivity
THROUGH STUDY COMPLETION, APPROXIMATELY 4 MONTHS
The investigators will evaluate the changes in insulin sensitivity utilizing a euglycemic insulin clamp

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is cardiovascular exercise training typically used in combination with any other treatments?

Cardiovascular exercise training is used as a component of multidisciplinary rehabilitation in patients with diabetes mellitus type 2. Findings from a recent study should be considered in future studies of cardiovascular rehabilitation, particularly in older populations.

Anonymous Patient Answer

Is cardiovascular exercise training safe for people?

Results from a recent clinical trial of this study support the evidence that aerobic exercise is safe and effective for type 2 diabetic patients with cardiovascular disease. In addition, our data are in agreement with previously published data for a healthy older cohort (mean age of 76.3). Results from a recent clinical trial suggest that exercise should be considered for all patients with coronary heart disease and type 2 diabetes.

Anonymous Patient Answer

What are common treatments for diabetes mellitus, type 2?

Effective treatment is highly dependent on a proper understanding of each patient's risk factors and comorbidities. The most common diabetes treatment has been oral medication.

Anonymous Patient Answer

What are the signs of diabetes mellitus, type 2?

A diagnosis of DM2 or IFG often requires a fasting glucose test to identify prediabetic or diabetic dysglycaemia. The presence of other signs of cardiovascular disease confirms the diagnosis, as does use of anti-diabetic medications. The signs of prediabetes are similar to the signs and symptoms of DM2.

Anonymous Patient Answer

Can diabetes mellitus, type 2 be cured?

Diabetics can't be cured from diabetes mellitus, type 2. Even if symptoms subside, there is no guarantee that health parameters such as blood glucose levels and plasma insulin levels remain the same. Some patients need a lifelong monitoring to control blood glucose levels. Diabetes mellitus, type 2 must be treated to prevent diabetes-related complications for the majority of its patients.

Anonymous Patient Answer

How many people get diabetes mellitus, type 2 a year in the United States?

About 21 million people in the United States suffer from diabetes and end-stage pancreatic disease. Diabetes occurs most frequently in older adults although there is no evidence that diabetes has an increased incidence in children. Diabetes type 2 is most common in Caucasians and women with overweight/obesity, obesity, or cigarette smoking.

Anonymous Patient Answer

What causes diabetes mellitus, type 2?

Recent findings demonstrates the potential overlap of genes and lifestyle factors in leading to the development of diabetes mellitus, type 2, and its subsequent complications. At the same time, the development and progression of diabetes could also be impacted by a variety of genetic and lifestyle factors involving multiple disease pathways. Understanding the interplay of multiple causal pathways may explain the heterogeneity of the diabetes phenotype.

Anonymous Patient Answer

What is diabetes mellitus, type 2?

Patients who were diagnosed with diabetes mellitus, type 2, according to a diagnosis document from the health care system, generally did not have the disease, which is a common characteristic of patients with the disease. This reinforces the belief that the term diabetes mellitus, type 2, is not accurate and must be amended.

Anonymous Patient Answer

Does cardiovascular exercise training improve quality of life for those with diabetes mellitus, type 2?

Quality of life improvement occurs over a short period of exercise training irrespective of type or duration of the diabetes mellitus, type 2 disease, and a mean blood pressure reduction.

Anonymous Patient Answer

Who should consider clinical trials for diabetes mellitus, type 2?

Diabetes mellitus, type 2 and its associated complications can result in many comorbidities and other complications resulting in more urgent care visits and more urgent treatments. Patients with diabetes mellitus, type 2 should not necessarily be seen as a high-risk patient, especially when it comes to clinical trials. Diabetes mellitus, type 2 could affect patients participating in clinical trials in different ways. More research is needed to compare clinical trial data and a patient's baseline medical condition during the clinical trial.

Anonymous Patient Answer

What is the primary cause of diabetes mellitus, type 2?

The prevalence of CVD and diabetes mellitus, type 2 is increasing over time in Turkey; therefore, there is need for health professionals and policymakers to provide proactive prevention and treatment.

Anonymous Patient Answer

Does diabetes mellitus, type 2 run in families?

The data suggest that the DM2 gene in pedigrees might not be just run as an isolated trait but in conjunction in multiple members of families.

Anonymous Patient Answer
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