Treatment for Opioid Abuse

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
UCLA Center for Behavioral and Addiction Medicine, Los Angeles, CA
Opioid Abuse+2 More
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a software program can improve opioid treatment outcomes in primary care settings.

See full description

Eligible Conditions

  • Opioid Abuse
  • Opioid Use Disorder (OUD)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 2 primary outcomes, 5 secondary outcomes, and 3 other outcomes in patients with Opioid Abuse. Measurement will happen over the course of Change from baseline treatment as usual (TAU) at post-intervention (from start of intervention through to study completion, up to 10 months).

Month 10
Additional healthcare utilization by patients
Counts of services/medications received by patients
Number and result of urine screening tests for buprenorphine, opioids (heroin, synthetics, fentanyl), cocaine, methamphetamine, benzodiazepines, cannabis
Number of visits scheduled and kept with PCP
Number of visits scheduled and kept with psychosocial providers
Month 10
Number of times OARS patient mobile application initiated
Number of times OARS platform initiated by provider
Return on Investment (ROI)
Type of feature and level of involvement with patient mobile application features
Use of OARS risk score per patients

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Treatment as Usual
1 of 2
Opioid Addiction Recovery Support (OARS)
1 of 2
Active Control

This trial requires 200 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Treatment as UsualData collected at baseline before OARS in conjunction with MOUD is implemented at study sites.
Opioid Addiction Recovery Support (OARS)
Other
Data collected post-implementation of OARS in conjunction with medication for opioid use disorder (MOUD) at study sites.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: post (oars) intervention through to study completion, up to 10 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly post (oars) intervention through to study completion, up to 10 months for reporting.

Closest Location

UCLA Center for Behavioral and Addiction Medicine - Los Angeles, CA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. You must have received 1 prior treatment for Opioid Abuse or one of the other 2 conditions listed above. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Physician, nurse practitioner, or physician's assistant in any area within primary care;
In possession of valid DATA-2000 waiver;
Currently treating more than two patients with OUD using oral buprenorphine-naloxone product;
Willing to distribute study materials to their patients describing the research and providing options for their participation.
Diagnosed and treated using MAT within primary care setting (i.e., family medicine, internal medicine, adolescent medicine, pediatrics, obstetrics/gynecology, geriatrics, infectious diseases, emergency department, non-cancer pain management).

Patient Q&A Section

Can opioid abuse be cured?

"Despite the progress that has been made in the last decades to educate the public about the risks of substance abuse, there are no effective drug therapies for treating substance use disorders, including opioid abuse. It should be carefully noted that the use of the term 'cure' implies that the problem is fundamentally 'cured,' and this in fact is not always the case in the treatment of substance abuse. Furthermore, the question of if drug therapy in itself could actually cure opioid addiction remains unanswered, and future treatment research is needed to explore this question. Nevertheless, a few studies have demonstrated a small but highly significant reduction in opioid use following the administration of buprenorphine or naltrexone." - Anonymous Online Contributor

Unverified Answer

What is opioid abuse?

"In recent years, opioid abusers who use heroin or heroin-like drugs are frequently also abusers of prescription and other prescription medications. Opioid users are at unusually risk of HIV infection.\n\nThe study found that a significant proportion of U.S. adults did not fully understand the disease, which in some cases could cause harm.\n\n"The New York Times" called the public health campaigns "an effective and expensive effort to reach many millions of Americans." "For every dollar spent on advertising, there were $7 in direct medical benefits," the report said. "In total, the program, as of 2005, had cost $38 billion, and had saved $2." - Anonymous Online Contributor

Unverified Answer

How many people get opioid abuse a year in the United States?

"Approximately 14.1 million American adults abused opioids in 2011. Of those, 22.8% became dependent on opioids and 20.5% abuse opioids. Male adult opioid abusers are more likely to abuse the drug." - Anonymous Online Contributor

Unverified Answer

What are common treatments for opioid abuse?

"Treatment of abuse includes behavioral interventions, such as behavioral change techniques and group support, naltrexone, agonist therapy and buprenorphine for opioid addiction. The treatment for co-morbid opioid use disorder depends on the drug of choice and the comorbid substance use. There is no cure for opioid abuse, and treatment focuses on the use of the medication, buprenorphine, as the main medication of treatment.\n\nThe following are some of the most common treatments for various diagnoses." - Anonymous Online Contributor

Unverified Answer

What causes opioid abuse?

"The main causes of opioid abuse are the need for medication and the user's expectations of its effects. As doctors prescribe opioids, they should be more alert to the risk of addiction. Furthermore, the user's awareness of the risks associated with prescription opioids could be improved if doctors and pharmacists trained the users on the risks of prescription opioids and on managing chronic pain with opioids." - Anonymous Online Contributor

Unverified Answer

What are the signs of opioid abuse?

"Among patients admitted with acute intoxication, the presence of a history of substance abuse or the use of any one class of substance other than alcohol or other sedatives had a strong predictive value for opioid-related behaviors. The history, use and/or history of marijuana use were associated with the presence of opioid-related behaviors." - Anonymous Online Contributor

Unverified Answer

What does treatment usually treat?

"More than half of respondents had difficulty in finding information pertaining to their treatment. Most respondents said they were satisfied with their treatment decisions, and the majority of respondents reported their treatment had had no effect on their health. There is a need for a clearer understanding of the factors that can affect people's treatment decisions." - Anonymous Online Contributor

Unverified Answer

Does treatment improve quality of life for those with opioid abuse?

"Evidence from this single-site randomised, controlled trial suggests that treatment of OAE improves QoL and reduces depressive symptoms, and should be considered in the treatment of OAE." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of opioid abuse?

"The findings corroborate the notion that the primary risk factor for opioid abuse is an unhealthy opioid-seeking coping strategy. Understanding the interaction of these factors will help researchers and stakeholders develop interventions that target high-risk groups for opioid abuse." - Anonymous Online Contributor

Unverified Answer

What is treatment?

"Patients with alcohol/drug problems will not change their drinking or drug use patterns. Those patients receiving treatment for these problems will typically also change their drinking or drug use patterns and thereby achieve important remission over a protracted period at lower levels of alcohol/drug use costs than those receiving no treatment at all." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in treatment for therapeutic use?

"Therapeutic use has evolved from the use of conventional opioids into a wide range of newer treatments designed to minimize the negative effects of pain, opioid-induced constipation, or opioid withdrawal upon the treatment of chronic pain and other conditions. Evidence suggests that newer pain treatments are effective, safe, and well tolerated. A growing body of evidence on newer therapeutic treatments has now been validated by meta-analyses that demonstrated substantial advantages over the conventional opioid medications. The more effective the treatment, the more patients and physicians are likely to use it. Given the growing demand for treatments to treat chronic pain, it seems clear that this field is in its infancy." - Anonymous Online Contributor

Unverified Answer

How does treatment work?

"When comparing opioid abusers and controls on the frequency of heroin use (which were measured by self-reports), non-treatment users reported more frequent heroin use and more intense use of heroin per session, than treatment users. In terms of more intense heroin use, results for treatment users were not significantly different than those for non-treatment users. For heroin use in general, results were significantly lower among treatment users but not non-treatment users." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Opioid Abuse by sharing your contact details with the study coordinator.