← Back to Search

Behavioural Intervention

Time restricted feeding arm for Obesity (TRIO Trial)

N/A
Waitlist Available
Research Sponsored by Rockefeller University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Normally sleep between the hours of 10 pm and 8 am
If taking probiotics during screening, must agree to continue taking them at the same dosage and frequency
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 2-day14
Awards & highlights

TRIO Trial Summary

This study is evaluating whether restricting the timing of caloric intake to earlier in the day may improve glycemia and inflammation in individuals with prediabetes and obesity.

Eligible Conditions
  • Obesity
  • Inflammatory Markers
  • Blood Sugar Variation
  • Time-Restricted Feeding
  • Ketosis

TRIO Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

TRIO Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 2-day14
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 2-day14 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in glycemic variation by mean amplitude of glycemic excursion (MAGE)
Change in inflammatory marker concentrations (sRAGE and hsCRP) relative to the UFP arm
Secondary outcome measures
Change in biological indices of appetite (incretins) in TRF arm relative to UFP arm.
Changes in WBC transcriptomic profiles versus UFP arm between1, 7 and 14 days.
Shift from glucogenic to ketogenic metabolism in the TRF arm relative to the UFP arm by plasma metabolomics
+1 more

TRIO Trial Design

2Treatment groups
Experimental Treatment
Group I: Usual feeding patternExperimental Treatment2 Interventions
Usual feeding pattern, then time restricted feeding Day 1 testing Day 2-7 all meals will be consumed as follows: Meals consumed ad lib with 50% of calories consumed after 4 PM. Day 8 testing. Day 9-14 crossover to time restricted feeding arm with all meals consumed as follows: 80% of calories consumed before 2 PM with remaining 20% consumed by 4PM. Fasting except for water, non caloric drinks for 14-16 hours Same number of calories consumed as in usual feeding pattern arm for 6 days.
Group II: Timed restricted feedingExperimental Treatment2 Interventions
Time restricted feeding then usual feeding pattern Day 1, testing Day 2-7 all meals will be consumed as follows: 80% of calories consumed before 2 PM with remaining 20% consumed by 4PM. Fasting except for water, non caloric drinks for 14-16 hours Same number of calories consumed as in usual feeding pattern arm. Day 8 testing. Day 9-14 crossover to usual feeding pattern arm (meals consumed ad lib with 50% of calories consumed after 4 PM) for 6 days.

Find a Location

Who is running the clinical trial?

Rockefeller UniversityLead Sponsor
158 Previous Clinical Trials
16,347 Total Patients Enrolled
18 Trials studying Obesity
327 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~3 spots leftby Mar 2025