Endodontic Regeneration for Tooth Diseases

Phase-Based Estimates
1
Effectiveness
1
Safety
Graduate Endodontic Clinic, Ann Arbor, MI
Tooth Diseases+3 More
Endodontic Regeneration - Procedure
Eligibility
< 65
All Sexes
Eligible conditions
Tooth Diseases

Study Summary

This study is evaluating whether one method of disinfecting and inducing blood clot formation is as effective as the other.

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Eligible Conditions

  • Tooth Diseases
  • Pulp Mummification
  • Necrosis
  • Disorder of Tooth Development
  • Dental Pulp Necrosis

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Endodontic Regeneration will improve 1 primary outcome and 1 secondary outcome in patients with Tooth Diseases. Measurement will happen over the course of Baseline and 24 months after the induction of blood clot.

Month 24
Absence of infection and inflammation.
Month 24
Changes in root length and canal wall width

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

No Control Group
Immediate Induction

This trial requires 45 total participants across 2 different treatment groups

This trial involves 2 different treatments. Endodontic Regeneration is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Immediate Induction
Procedure
Blood clot is induced after disinfection of the canal during the same visit. Endodontic regeneration is performed.
Delayed induction
Procedure
The root canal is disinfected and calcium hydroxide is placed in the canal. Blood clot is induced in the canal 4 weeks later. Endodontic Regeneration is performed.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 and 24 months after the induction of blood clot
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 12 and 24 months after the induction of blood clot for reporting.

Who is running the study

Principal Investigator
T. B.
Prof. Tatiana Botero, Clinical Associate Professor
University of Michigan

Closest Location

Graduate Endodontic Clinic - Ann Arbor, MI

Eligibility Criteria

This trial is for patients born any sex aged 65 and younger. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The tooth is able to be restored and it is stable when the periodontal tissues are healthy. show original
The clinical diagnosis of pulp necrosis is based on a cold test, electric pulp test, and an identified cause of pulp necrosis such as caries, deep restorations, dental anomalies, history of trauma, and associated with radiographic and/or clinic signs of a periapical lesion. show original
Use a drill bit with a diameter of at least 1mm to open the apex of the tooth show original
The patient should be in good health or have a minor systemic disease with no contraindications to the treatment. show original
Cooperative means working together. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes tooth diseases?

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There was strong evidence that gum disease increases the risk of tooth decay and root decay. Low-level evidence supported a modestly statistically significant association between tooth disease and periodontitis. For tooth infection, there was conflicting evidence. What causes tooth decay? answer: There was strong evidence that tooth decay is most strongly associated with high levels of sugar consumption, followed by high levels of sugar consumption and drinking of sugar-sweetened beverages containing excess sugars. What causes periodontal disease? There is moderate evidence that smoking is the most important risk factor for periodontal disease, with some evidence that poor oral hygiene and/or poor oral clearance reduces risk.

Unverified Answer

Can tooth diseases be cured?

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There is no way for a tooth to be cured. Instead, a lot can be done by the patient and his/her friends, who tend to be the most influential. Teeth can be kept free of pain by good oral hygiene with regular cleanings and fluoride treatments. Appropriate health education is also important.

Unverified Answer

What are common treatments for tooth diseases?

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The majority of children with tooth diseases receive treatment for them from a dental health professional in a dental setting. For some parents, though, the best treatment is from home remedies. For some parents, though, home remedies alone fail to completely relieve the symptoms of tooth decay-related pain. For some patients, dental treatment as an alternative could be an attractive option in the dental hygiene market, due to the lack of dental insurance. Some patients prefer to seek other sources of treatment when home remedies fail to succeed or are ineffective.

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How many people get tooth diseases a year in the United States?

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Around 7.2 million Americans have at least one tooth disorder a year, and 1.9 million of those do not have a dentist. The most common tooth disorders are impacted teeth, dental cavities, and dental fillings. Most patients reported getting their diagnosis from a family doctor or dentist.

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What is tooth diseases?

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Tooth disease is the result of deterioration of the teeth that can occur through either dental caries, periodontal disease or trauma. Dental restoration and maintenance of teeth involves keeping the oral cavity free of dental caries and periodontal disease; this can be difficult for people with intellectual disabilities and complex psychiatric disorders unless dental health is addressed and specialised services available onsite along with the local population.

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What are the signs of tooth diseases?

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The most commonly reported symptom was pain to which patients assigned it. The second strongest symptom was gingival bleeding and periodontal pocketing. We found that approximately one-third of the patients had a periodontal pocket. Considering its frequency, periodontal pocketing and gingival bleeding were considered to be the most important indicators of tooth diseases.

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What is the primary cause of tooth diseases?

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The most common causes of tooth diseases, in order of frequency, were lack of saliva, acidic drinks, cigarette smoking, and poor plaque control. More information is needed to inform the public about what cause tooth diseases.

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What is endodontic regeneration?

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[The aim of the paper is to encourage a more balanced, objective discussion about endodontic regeneration through the provision of appropriate and accessible links to appropriate clinical evidence.] As a matter of fact, the endocanal biopsy is a quick, easy and inexpensive procedure to evaluate the endodontic regeneration. In our opinion, it can be helpful to provide the patients with patients at the same time that the treatment plan is being decided. The use of a non-invasive, painless diagnostic tool, could be useful to provide patients with an objective, fast decision-making approach. Moreover, we think the study by Jaffe et al.

Unverified Answer

Is endodontic regeneration typically used in combination with any other treatments?

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In patients with necrotizing ulcerative gingivitis, it is highly likely that root canal treatments will fail. It is therefore recommended that both endodontic and surgical regimens require a combined plan. Endodontic therapy should not be used as a definitive treatment on its own for necrotizing ulcerative gingivitis patients.

Unverified Answer

What are the common side effects of endodontic regeneration?

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The main side effects of endodontic regeneration are pain, bleeding, swelling and trismus. Endodontic treatment can affect the tooth root in an area depending on its location, the position of the tooth, the amount of treatment, and the amount of bone remodeling. The duration of the treatment can also influence the results, especially when the tooth is root-filled.

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How serious can tooth diseases be?

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Although there are many instances of tooth diseases, very few teeth become fractured. The vast majority of oral injuries are minor and can heal on their own without treatment. Dentists and dental hygienists can help prevent dental emergencies by ensuring that your oral care routine includes brushing and flossing daily, regular review by the hygiene team, and regular dental check-ups. When the situation is considered serious (e.g., facial fractures, teeth that are on the verge of eruption, teeth that are already fractured, and tooth loss), dental emergencies should always be addressed promptly. There are many different tooth treatments that may be used, depending on the patient's circumstances. These treatments may involve restorative or non-restorative treatments.

Unverified Answer

Is endodontic regeneration safe for people?

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The risks from endodontic and perforation were comparable and endodontic treatments, especially when undertaken by experienced treatment teams, were safe for people in routine day practise.

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