Resistance Exercise for Non-Small Cell Lung Carcinoma (NSCLC)

Phase-Based Progress Estimates
University of South Carolina, Columbia, SC
Non-Small Cell Lung Carcinoma (NSCLC)+2 More
Resistance Exercise - Behavioral
All Sexes
Eligible conditions

Study Summary

This study is evaluating whether a home-based exercise program can improve symptoms of dyspnea and fatigue in people with non-small cell lung cancer.

See full description

Eligible Conditions

  • Non-Small Cell Lung Carcinoma (NSCLC)
  • Resistance Exercise

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Non-Small Cell Lung Carcinoma (NSCLC)

Study Objectives

This trial is evaluating whether Resistance Exercise will improve 3 primary outcomes and 14 secondary outcomes in patients with Non-Small Cell Lung Carcinoma (NSCLC). Measurement will happen over the course of Baseline and post intervention (8-weeks).

Baseline and post intervention (8-weeks)
Appendicular Lean Mass
Body Fat Percentage
Bone Mineral Density
Fat Free Mass
Fat Mass
Lower Body Muscular Strength
Lung Cancer Related Quality of Life
Physical Function 6MWT
Physical Function STS
Total Mass
Upper Body Muscular Strength
Post-Intervention (8-weeks)
Year 1
Intervention Fidelity

Trial Safety

Safety Progress

1 of 3

Other trials for Non-Small Cell Lung Carcinoma (NSCLC)

Trial Design

1 Treatment Group

Exercise Intervention
1 of 1
Experimental Treatment

This trial requires 15 total participants across 1 different treatment group

This trial involves a single treatment. Resistance Exercise is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Exercise Intervention
First Studied
Drug Approval Stage
How many patients have taken this drug
Resistance Exercise
Completed Phase 4

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: through study completion, an average of 1 year
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly through study completion, an average of 1 year for reporting.

Who is running the study

Principal Investigator
C. F.
Prof. Ciaran Fairman, Assistant Professor
University of South Carolina

Closest Location

University of South Carolina - Columbia, SC

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Completed definitive treatment for localized NSCLC (stages I-III)
Has access to stable internet access for Zoom participation
Willing to complete an 8-week, home-based intervention program that includes face-to-face and Zoom interaction.
Willing to consider behavior change at this time.
Able to speak and read English.
Capable of informed consent
Has obtained medical clearance from medical practitioner or medical team

Patient Q&A Section

What does resistance exercise usually treat?

"Resistance exercise has a beneficial effect on numerous aspects of health such as cardiovascular fitness, muscle strength, bone density, insulin sensitivity, triglycerides, HDL-cholesterol and inflammation. In addition, resistance exercise may be able to reduce insulin resistance, gestational diabetes mellitus, atherosclerosis, hypertension, obesity and body fat distribution. It is suggested that resistance exercise should be recommended to patients suffering from pulmonary diseases to improve exercise tolerance, pulmonary function and quality of life." - Anonymous Online Contributor

Unverified Answer

What is the latest research for lung cancer?

"There have been major advances in both basic and clinical lung cancer research over the past decade. This article covers the most current findings on diagnosis, treatment, and prognosis of lung cancer, including the role of epigenetics in development and progression of lung cancer and the use of targeted therapy with epidermal growth factor receptor inhibitors. It should be stressed that most of the changes over recent years have occurred within the last decade. Still, significant progress has been made in prevention, which includes screening and the use of new diagnostic techniques. Current research efforts are focusing on developing new treatments and better understanding the mechanisms that drive lung cancer progression." - Anonymous Online Contributor

Unverified Answer

Can lung cancer be cured?

"The survival rate for stage IV NSCLC is poor. In this population, most patients die of other causes than from their primary tumor; however, if the patient survives long enough, they may succumb to the effects of their metastatic disease." - Anonymous Online Contributor

Unverified Answer

What is lung cancer?

"The word 'cancer' is derived from two Greek words; "karkinos" meaning flesh and "karrino" meaning growth. The Latin term "carcinoma" means 'tumor of flesh'. Lung cancer is an umbrella term for a group of cancers of the lung and bronchi which all share certain characteristics of origin, progression, and behavior. They include transitional cell carcinoma of the lung, squamous cell carcinoma of the lung, small cell carcinoma of the lung, and adenocarcinoma of the lung. The pathogenesis of lung cancer remains largely unknown, but it most likely involves genetic predisposition and environmental factors." - Anonymous Online Contributor

Unverified Answer

Is resistance exercise safe for people?

"Resistance exercise was well tolerated, but patients had lower baseline VO2max and muscle strength compared to controls. The difference in strength was exacerbated by intensity; not only was it greater than that reported from conventional training, but also exceeded the threshold for an increase in muscle damage. In addition, there was no evidence of increased bleeding risk following resistance exercise, while traditional training was associated with a significant increase in haematocrit. Data from a recent study suggest caution regarding the use of resistance exercise as a means of increasing aerobic capacity for older patients with cardiovascular disease." - Anonymous Online Contributor

Unverified Answer

What is resistance exercise?

"RESULTS suggest that resistance training should be incorporated into lung cancer treatment regimes as a means of improving muscle strength and reducing fatigue associated with lung cancer treatments." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in resistance exercise for therapeutic use?

"A new approach to increasing exercise output for use in rehabilitation has been developed. The method involves taking the response to exercise training during a bout of intense exercise and using it to guide the choice of exercise intensity during subsequent bouts. The resulting 'training set' is used to increase exercise output after recovery. This may be of particular value in patients whose exercise responses are impaired due to illness, injury or age. Further studies are required to evaluate the effect of this method on functional outcomes." - Anonymous Online Contributor

Unverified Answer

What is the survival rate for lung cancer?

"The survival rate for lung cancer patients depends on several factors including patient age, sex, histopathological subtype, stage, and treatment modality. The five-year relative survival rate for patients with adenocarcinoma is approximately 32%, compared with about 65% for patients with squamous cell carcinoma. Most lung cancers occur in people who are in their fifties and sixties." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving resistance exercise?

"RESULTS suggest that resistance exercise can improve almost every aspect of quality of life. A larger randomized controlled trial with a long follow-up period is needed to confirm these findings." - Anonymous Online Contributor

Unverified Answer

What are common treatments for lung cancer?

"Although there is much overlap among different types of lung cancers, there is also a significant degree of variation among the treatments used. Findings from a recent study provides a comprehensive review of the current status of lung cancer therapy." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating lung cancer?

"Although some research has been conducted, as far as I know, none has produced significant treatment advances for patients with lung cancer. Moreover, the research that has been done seems to indicate that further treatment advances are unlikely to occur soon. The studies seem to show that lung cancer cannot be cured, although the signs and symptoms can be greatly reduced.\n\nThe FDA approved several treatment options for patients with lung cancer in 2017, but there are still limitations to using these drugs. Several recent studies suggest that there are new treatment options in development, which could eventually affect how patients are treated." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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