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Viability Assessment Technology for Liver Transplantation

N/A
Waitlist Available
Led By Heidi Yeh, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Male or female 18-75 years of age
Candidate for a deceased-donor liver allograft
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This trial is testing if a new technology can improve discarded liver grafts to the point of being transplantable. If successful, this will help develop a way to measure the viability of machine perfused livers.

Who is the study for?
This trial is for men and women aged 18-75 who are candidates for a liver transplant from a deceased donor. It's not open to individuals who test positive for HIV-1.Check my eligibility
What is being tested?
The study is testing the use of machine perfusion technology on discarded liver grafts. It involves taking biopsies before and after implantation to develop an index that can predict how well the liver will function post-transplant.See study design
What are the potential side effects?
Since this trial involves standard procedures associated with liver transplantation, potential side effects may include complications from biopsy such as pain, bleeding, or infection.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 75 years old.
Select...
I am eligible for a liver transplant from a deceased donor.
Select...
I am between 18 and 75 years old.
Select...
I am eligible for a liver transplant from a deceased donor.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Peak transaminase value post transplant
Secondary outcome measures
Acute Liver Rejection
Biliary Complications
Death
+4 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: BiopsyExperimental Treatment1 Intervention
Biopsies taken at protocol specified time points
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Liver Biopsy
2015
N/A
~270

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,918 Previous Clinical Trials
13,192,775 Total Patients Enrolled
8 Trials studying Liver Cirrhosis
610 Patients Enrolled for Liver Cirrhosis
ShrinersUNKNOWN
Shriner'sUNKNOWN

Media Library

Liver Biopsy Clinical Trial Eligibility Overview. Trial Name: NCT03694691 — N/A
Liver Cirrhosis Research Study Groups: Biopsy
Liver Cirrhosis Clinical Trial 2023: Liver Biopsy Highlights & Side Effects. Trial Name: NCT03694691 — N/A
Liver Biopsy 2023 Treatment Timeline for Medical Study. Trial Name: NCT03694691 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who meets the qualifications for involvement in this experimental trial?

"This clinical study seeks 60 individuals, aged 18-75 years old, with pre-existing liver cirrhosis. To be eligible for the trial one must adhere to both gender and age restrictions as well as hold candidacy for deceased donor liver transplantation."

Answered by AI

Does this research permit individuals below the age of 30 to participate?

"This clinical trial requires that potential participants must be between 18 and 75. For those ineligible for this study, there are 11 trials open to minors and 212 trials available for seniors."

Answered by AI

Is this trial currently recruiting participants?

"According to the information listed on clinicaltrials.gov, this trial has stopped accepting applicants as of September 1st 2021. Initially posted October 1st 2018, it is not currently contributing towards recruiting patients for medical studies; however, there are 221 other trials looking for volunteers now."

Answered by AI

Who else is applying?

What state do they live in?
Connecticut
How old are they?
18 - 65
What site did they apply to?
Massachusetts General Hospital
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0
~9 spots leftby Mar 2025