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Thyroid Hormone Replacement

Thyroid Hormone Therapy for Hypothyroidism

N/A
Waitlist Available
Research Sponsored by Walter Reed National Military Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Subjects will be between the ages of 18 to 65 and will have been on levothyroxine for primary hypothyroidism for at least 6 months
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Study Summary

This trial is a study to compare the effect of different thyroid treatments on memory and other symptoms in patients with hypothyroidism.

Who is the study for?
This trial is for Department of Defense beneficiaries near Bethesda, MD, aged 18-65 with primary hypothyroidism treated with levothyroxine for at least 6 months. Exclusions include pregnancy or planning to become pregnant, heart and lung diseases, severe kidney/liver issues, certain mental health conditions, and those on specific medications.Check my eligibility
What is being tested?
The study compares three thyroid hormone treatments: desiccated thyroid extract (DTE), synthetic T3/T4 combo (ThyrolarTM), and L-T4 alone in a blinded crossover design. Participants will switch between treatments every three months to assess effectiveness on memory, well-being, and other health parameters.See study design
What are the potential side effects?
Potential side effects may include changes in energy levels, heart rate irregularities due to altered thyroid hormone levels; skin reactions; gastrointestinal disturbances like diarrhea or constipation; weight fluctuations; and possible allergic reactions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18-65 years old and have been taking levothyroxine for my thyroid condition for at least 6 months.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Beck Depression Inventory
QOL as measured by General Health Questionnaire (GHQ)-12
Thyroid Symptom Questionnaire (TSQ)
+1 more

Trial Design

3Treatment groups
Active Control
Group I: Levothyroxine Plus Liothyronine GroupActive Control1 Intervention
Levothyroxine Plus Liothyronine Group
Group II: Levothyroxine GroupActive Control1 Intervention
Levothyroxine Group
Group III: Desiccated Thyroid Extract GroupActive Control1 Intervention
Desiccated Thyroid Extract Group

Find a Location

Who is running the clinical trial?

Walter Reed National Military Medical CenterLead Sponsor
136 Previous Clinical Trials
37,254 Total Patients Enrolled
1 Trials studying Hypothyroidism
180 Patients Enrolled for Hypothyroidism

Media Library

Desiccated Thyroid Extract (Thyroid Hormone Replacement) Clinical Trial Eligibility Overview. Trial Name: NCT02317926 — N/A
Hypothyroidism Research Study Groups: Levothyroxine Plus Liothyronine Group, Levothyroxine Group, Desiccated Thyroid Extract Group
Hypothyroidism Clinical Trial 2023: Desiccated Thyroid Extract Highlights & Side Effects. Trial Name: NCT02317926 — N/A
Desiccated Thyroid Extract (Thyroid Hormone Replacement) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02317926 — N/A
Hypothyroidism Patient Testimony for trial: Trial Name: NCT02317926 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you elaborate on prior research conducted with the Levothyroxine Plus Liothyronine Group?

"Presently, 17 clinical trials are assessing the efficacy of Levothyroxine Plus Liothyronine Group with 4 studies reaching Phase 3. Of these 58 trial sites based in Jinan, Shandong province, some are evaluating this drug combination."

Answered by AI

What conditions is the Levothyroxine Plus Liothyronine Group typically employed to treat?

"Levothyroxine Plus Liothyronine Group is an approved therapeutic intervention for a variety of thyroid-related diseases, including myxedema pre-coma and euthyroid goitre. Additionally, it can be prescribed as supplemental or replacement therapy."

Answered by AI

Is enrolment for this experiment still open?

"Unfortunately, the data on clinicaltrials.gov suggests that this trial has ended its recruitment process as it was last updated on May 5th 2015. However, there are 30 other studies actively seeking new participants right now."

Answered by AI

Are adults aged 30 or more suitable candidates for this experiment?

"This clinical trial is recruiting participants over the age of 18 and not yet 65 years old."

Answered by AI

What criteria must individuals meet to qualify for participating in this clinical experiment?

"To be accepted into this clinical trial, candidates must have hypothyroidism and fit within the 18 to 65 years old age bracket. This medical study will recruit a total of 81 people."

Answered by AI

What is the size of the sample group engaged in this clinical experiment?

"At this moment, enrolment for the trial has been suspended. Initially posted on May 1st 2015 and most recently updated on 5/5/2015, participants are no longer being accepted. Nevertheless, there remain 13 studies recruiting individuals with hypothyroidism and 17 trials actively searching for patients in Levothyroxine Plus Liothyronine Group."

Answered by AI

Who else is applying?

What state do they live in?
Virginia
What site did they apply to?
Walter Reed National Military Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1

What questions have other patients asked about this trial?

How long will it take to know if I have made it into the trial?
PatientReceived 1 prior treatment

Why did patients apply to this trial?

I have been on synthroid for 11 years, over the last 3 years my dosage keeps increasing with little to no change in symptoms. I am Active duty Army stationed at Fort Eustis, I want to find Releif along with helping to get better treatment for others in my situation.
PatientReceived no prior treatments
~8 spots leftby Mar 2025