CLINICAL TRIAL

Walking for Depression

Recruiting · 18+ · All Sexes · Seattle, WA

Multiphase Optimization Trial of Incentives for Veterans to Encourage Walking

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About the trial for Depression

Eligible Conditions
Depression · Walking · Exercise · Hypertension · Body Mass Index · Motivation · Sedentary Behaviors

Treatment Groups

This trial involves 16 different treatments. Walking is the primary treatment being studied. Participants will be divided into 16 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Walking
BEHAVIORAL
Experimental Group 2
Walking
BEHAVIORAL
Experimental Group 3
Walking
BEHAVIORAL
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About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Walking
2016
Completed Phase 2
~1680

Eligibility

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Veteran that receives healthcare at VA Puget Sound Health Care System
Age 50-69
Diagnosis of hypertension, depression or a BMI between 25-40.
Physically inactive according to self-report. .
2,000-5,000 steps per day during the screening week
Have and be able to use a smart phone.
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Measured at baseline, week 12 and 24
Screening: ~3 weeks
Treatment: Varies
Reporting: Measured at baseline, week 12 and 24
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Measured at baseline, week 12 and 24.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Walking will improve 1 primary outcome and 3 secondary outcomes in patients with Depression. Measurement will happen over the course of baseline to week 12.

Change in average steps per day from baseline week to week 12
BASELINE TO WEEK 12
The change in average steps per day from the baseline week to week 12.
BASELINE TO WEEK 12
Mental health
MEASURED AT BASELINE, WEEK 12 AND 24
Measured using the PHQ-8 depression scale at baseline, week 12 and week 24. This assessment measures depressive symptoms over the past 2 weeks. Respondents indicate how bothered they were by the following problems on a scale from 0 (not at all) to 3 (nearly every day). A lower score indicates fewer depressive symptoms.
MEASURED AT BASELINE, WEEK 12 AND 24
Intrinsic/extrinsic motivation
MEASURED AT BASELINE, WEEK 12 AND 24
Measured using the Motivation for Physical Activity Measurement (MPAM) at baseline, week 12 and week 24 (Frederick CM 1993). This scale measures reasons and motivations for participating in physical activity having respondents indicate why they exercise. The scale ranges from 1=very true for me, 2= somewhat true for me, 3=neither true nor untrue for me, 4=somewhat untrue for me, 5= very untrue for me.
MEASURED AT BASELINE, WEEK 12 AND 24
Self-efficacy
MEASURED AT BASELINE, WEEK 12 AND 24
Measured using the Exercise Self-Efficacy Scale at baseline, week 12 and week 24 (McAuley E 1993). This scale measures self-efficacy on nine different measures from not confident (0 rating) to very confident (10 rating). A higher rating indicates that the respondent is more confident they will be able to overcome barriers to physical activity.
MEASURED AT BASELINE, WEEK 12 AND 24

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the common side effects of walking?

In a recent study, findings the most common side effects of walking in patients who participated in exercise training were low back pain and hypotension.

Anonymous Patient Answer

Is walking safe for people?

There are a number of barriers to walking that might prevent some people from walking. Strategies such as building community networks and increased awareness of the physical and behavioural barriers to walking and ensuring that the environment is safe and comfortable and is compatible with safety measures are needed to improve people's walking rates.

Anonymous Patient Answer

How serious can depression be?

There are a number of treatments for severe depression and there are many different criteria for how this can be tested. There is some evidence of effectiveness from randomised controlled trials, although many trials in this area are of poor quality. Depression affects between 1 and 2% of the population and is the most devastating health problem globally.

Anonymous Patient Answer

What are the signs of depression?

Depression is a symptom complex; the clinical experience of clinicians is very varied, and signs vary enormously among individuals. Depression most often manifests in a chronic course. The severity and rate of recovery of the depression are unpredictable. Effective psychiatric drugs may be used and recovery complete and sustained. The clinical approach to these drugs is very variable. There is no universally accepted diagnostic model. In the future, it is likely that the pathophysiologizing of depression may be more important than the symptomatology of the illness. However, we can be confident that there are many common sign and symptoms which can be used to elicit a diagnosis of depression.

Anonymous Patient Answer

How many people get depression a year in the United States?

The estimated number of people who will develop depression during their lifetime or during a year in the United States is approximately 5.4 million people.

Anonymous Patient Answer

What causes depression?

The main cause of depression is biological. Depression is sometimes caused by trauma, and anxiety may have a genetic influence. Depression in later life may be a result of biological factors, such as changes in the hormonal system.

Anonymous Patient Answer

What is depression?

Depressed women are far less likely to have children than not depressed women. As women live longer, their children tend to be older and have children at a greater rate so the rate of depression for women rises over time.

Anonymous Patient Answer

Can depression be cured?

The incidence of chronic depression is high (50% of the total population sample). Chronic depression can not be cured, but it can be controlled, especially with antidepressant medication.

Anonymous Patient Answer

What are common treatments for depression?

The World Health Organization's (WHO) 2014 global report on Depression for Children and Adolescents states that: “A substantial proportion of children and adolescents worldwide suffer from depression and that the disability-adjusted life years (DALYs) that result from this illness, is a major public health issue.”\n\nThere is evidence in the literature that, with proper management, most cases of depression are manageable and are successfully responsive to treatment.\n\n- "

"Hematophilia B test\n\nHematophilia B test is a hemoglobin based test, used for diagnosing hereditary partial or complete absence of factor IX.

Anonymous Patient Answer

What is the latest research for depression?

Although the findings of this review are promising and warrant further investigation, the paucity of high-quality randomized controlled studies limits interpretation of the effectiveness of depression treatments. Also, the findings may be biased by the nature of the reviews. Our search in the major medical databases found only 23 studies and 11 of these were not in the MEDLINE registry. Although authors’ comments might be informative, more rigorous methods are needed to facilitate a complete review of evidence.

Anonymous Patient Answer

Has walking proven to be more effective than a placebo?

The present study provides strong evidence that a walking programme is as effective as placebo for reducing depressive symptoms. We believe that walking could be effective as a preventive measure for the risk of depression.

Anonymous Patient Answer

Is walking typically used in combination with any other treatments?

Walking as an activity during treatment seems to have both advantages and disadvantages. Use of walking for exercise may be beneficial for patients with [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain) because it allows exercise of the lower limbs and reduces their pain by producing a sensation of exercise, which strengthens muscles and improves self-efficacy.

Anonymous Patient Answer
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