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Renal Denervation

Renal Denervation for High Blood Pressure

N/A
Waitlist Available
Led By Raymond Townsend, MD
Research Sponsored by Medtronic Vascular
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from 1 month to 36 months post-procedure
Awards & highlights

Study Summary

This trial is testing whether a medical procedure to nerve endings in the kidney can lower blood pressure, and whether it is safe to do without other blood pressure medications.

Eligible Conditions
  • High Blood Pressure
  • Cardiovascular Disease
  • Vascular Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from 1 month to 36 months post-procedure
This trial's timeline: 3 weeks for screening, Varies for treatment, and from 1 month to 36 months post-procedure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Baseline Adjusted Change (Using Analysis of Covariance) in Systolic Blood Pressure as Measured by 24-hour Ambulatory Blood Pressure Monitoring
Number of Participants With Major Adverse Events (MAE) Defined as a Composite of Events.
Secondary outcome measures
Baseline Adjusted Change (Using Analysis of Covariance) in Office Systolic Blood Pressure
Change in Diastolic Blood Pressure as Measured by 24-hour Ambulatory Blood Pressure Monitoring (ABPM)
Change in Office Diastolic Blood Pressure
+25 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Renal DenervationExperimental Treatment1 Intervention
Renal angiography and Renal Denervation (Symplicity Spyral™ multi-electrode renal denervation system)
Group II: Sham ProcedurePlacebo Group1 Intervention
Renal angiography
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Symplicity Spyral™ multi-electrode renal denervation system
2015
N/A
~370

Find a Location

Who is running the clinical trial?

Medtronic VascularLead Sponsor
65 Previous Clinical Trials
55,696 Total Patients Enrolled
Raymond Townsend, MDPrincipal InvestigatorUniversity of Pennsylvania
3 Previous Clinical Trials
428 Total Patients Enrolled
Michael Böhm, MDPrincipal InvestigatorUniversitätskliniken des Saarlandes
7 Previous Clinical Trials
2,655 Total Patients Enrolled

Media Library

Renal Denervation (Renal Denervation) Clinical Trial Eligibility Overview. Trial Name: NCT02439749 — N/A
High Blood Pressure Research Study Groups: Sham Procedure, Renal Denervation
High Blood Pressure Clinical Trial 2023: Renal Denervation Highlights & Side Effects. Trial Name: NCT02439749 — N/A
Renal Denervation (Renal Denervation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02439749 — N/A
High Blood Pressure Patient Testimony for trial: Trial Name: NCT02439749 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are the criteria for this clinical trial compatible with my medical history?

"Aspiring participants must have a pre-existing cardiovascular condition and be aged between 20 to 80. The total number of enrollees is set at 366 individuals."

Answered by AI

Are there currently opportunities to join this research program?

"According to clinicaltrials.gov, the trial is no longer actively recruiting; it was initially posted on June 1st 2015 and last updated on October 21st 2022. That said, there are 1191 other studies enrolling patients right now."

Answered by AI

Are individuals aged fifty and above being considered for this experiment?

"The eligibility requirements for this research set the age limit between 20 and 80, leaving out those under 18 or over 65. Conveniently, there are 82 trials available for younger patients, and 1059 studies accessible to elderly participants."

Answered by AI

To what extent have medical facilities embraced this research endeavor?

"The trial is including patients from Centennial Medical Center in Nashville, Tennessee; Stanford Hospital and Clinics in Stanford, California; Yale New Haven Hospital in New Haven, Connecticut as well as 32 other healthcare facilities."

Answered by AI

Who else is applying?

What state do they live in?
California
Alabama
Texas
How old are they?
65+
What site did they apply to?
Kaiser Permanente LA Medical Center
University of Kentucky
Mount Sinai Medical Center
Other
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
1

Why did patients apply to this trial?

I’m always trying to improve my overall health & well-being. It would be interesting to me to see if I could be off blood pressure medicine.
PatientReceived no prior treatments
Recent research and studies
~38 spots leftby Mar 2025