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Cathodal tDCS + rTMS then Anodal tDCS + rTMS then Sham tDCS + rTMS for Healthy Subjects

N/A
Waitlist Available
Led By Davin Quinn, M.D.
Research Sponsored by University of New Mexico
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Must be at least 18 years of age (all genders, races, ethnicity)
Must have no current psychiatric or neurologic issues
Timeline
Screening 3 weeks
Treatment Varies
Follow Up the final outcome will be percent change in the reaction time from pre- to post- intervention.
Awards & highlights

Study Summary

The overall objective is to validate the methodology of a metaplasticity experimental design by assessing change in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by repetitive transcranial magnetic stimulation (rTMS) in healthy human participants.

Eligible Conditions
  • Healthy Subjects

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~assessed and reported throughout study completion pre- and post- intervention approximately 30 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and assessed and reported throughout study completion pre- and post- intervention approximately 30 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percent Change in MEP Amplitude
Secondary outcome measures
Cortical Silent Period
Simple Reaction Time

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: Cathodal tDCS + rTMS then Anodal tDCS + rTMS then Sham tDCS + rTMSActive Control1 Intervention
Participant will receive 10 minutes of cathodal tDCS between M1 and M2 timepoints, and rTMS for 900 1Hz pulses at 0.85 of Resting Motor Threshold at M2. After 1 week washout, participant will receive 10 minutes of anodal tDCS and rTMS for 900 1Hz pulses at 0.85 RMT. After 1 week washout, participant will receive 10 minutes of sham tDCS and rTMS for 900 1 Hz pulses at 0.85 RMT.
Group II: Anodal tDCS + rTMS then Sham tDCS + rTMS then Cathodal tDCS + rTMSActive Control1 Intervention
Participant will receive 10 minutes of anodal tDCS between M1 and M2 timepoints, and rTMS for 900 1Hz pulses at 0.85 of Resting Motor Threshold at M2. After 1 week washout, participant will receive 10 minutes of sham tDCS and rTMS for 900 1 Hz pulses at 0.85 RMT. After 1 week washout, participant will receive 10 minutes of cathodal tDCS and rTMS for 900 1 Hz pulses at 0.85 RMT.
Group III: Sham tDCS + rTMS then Cathodal tDCS + rTMS then Anodal tDCS + rTMSPlacebo Group1 Intervention
Participant will receive 10 minutes of sham tDCS between M1 and M2 timepoints, and rTMS for 900 1Hz pulses at 0.85 of Resting Motor Threshold at M2. After 1 week washout, participant will receive 10 minutes of cathodal tDCS and rTMS for 900 1 Hz pulses at 0.85 RMT. After 1 week washout, participant will receive 10 minutes of anodal tDCS and rTMS for 900 1 Hz pulses at 0.85 RMT.

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Who is running the clinical trial?

University of New MexicoLead Sponsor
371 Previous Clinical Trials
3,529,028 Total Patients Enrolled
Davin Quinn, M.D.Principal InvestigatorUniversity of New Mexico
Sarah Pirio Richardson, M.D.Principal InvestigatorUniversity of New Mexico

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~2 spots leftby Mar 2025