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Other
Subjects with Type 2 Diabetes for High Blood Sugar
N/A
Waitlist Available
Led By Robert Sherwin, MD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age 18-55
BMI 18-45 kg/m^2
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 hours post hyperglycemia
Awards & highlights
Study Summary
This trial will use magnetic resonance spectroscopy (MRS) to measure levels of metabolites in the brain and plasma, before and after inducing hyperglycemia. Subjects will also have a lumbar puncture to assess cerebrospinal fluid levels of metabolites.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 4 hours post hyperglycemia
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 hours post hyperglycemia
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Metabolite Measurements by MRS
Secondary outcome measures
Cognitive State
Hunger Ratings
Satiety Ratings
Other outcome measures
Cerebrospinal fluid cell count
protein levels
Trial Design
3Treatment groups
Active Control
Group I: Subjects with Type 2 DiabetesActive Control2 Interventions
Type 2 DM subjects with HbA1C > 7.5% treated with metformin, sulfonylurea, insulin or combination
Group II: Non-Diabetic ObeseActive Control2 Interventions
Age-matched, non-diabetic obese (BMI > 30 kg/m^3) individuals
Group III: Lean, healthy control subjectsActive Control2 Interventions
Age-matched, lean, healthy control subjects (BMI < 25 kkg/m^3)
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Who is running the clinical trial?
American Diabetes AssociationOTHER
137 Previous Clinical Trials
99,364 Total Patients Enrolled
Yale UniversityLead Sponsor
1,839 Previous Clinical Trials
2,728,904 Total Patients Enrolled
Robert Sherwin, MDPrincipal InvestigatorYale University
7 Previous Clinical Trials
217 Total Patients Enrolled
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