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RBC Transfusion Strategies for Subarachnoid Hemorrhage

N/A
Recruiting
Led By Shane English, MD MSc FRCPC
Research Sponsored by Ottawa Hospital Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
First ever episode of aneurysmal SAH
Diagnosis of aSAH as confirmed by treating physician (eg: neurosurgeon or neuro- interventionalist) and supported by blood in subarachnoid space (e.g. cranial imaging or cerebrospinal fluid positive for xanthochromia, surgical visualization) that is the result of a ruptured aneurysm (e.g. direct visualization, cranial imaging or catheter angiogram)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months post
Awards & highlights

Study Summary

This trial will help determine the best way to treat anemia in patients with aSAH, and whether doing so impacts mortality and functional outcomes.

Who is the study for?
The SAHaRA trial is for adults over 18 who've had their first brain aneurysm bleed. They must have low hemoglobin levels within 10 days of the event and confirmed diagnosis by a specialist. It's not for those with ongoing severe bleeding, decisions to limit care, objections to blood transfusions, or aneurysms caused by infections or malformations.Check my eligibility
What is being tested?
This study compares two strategies for blood transfusion in patients with brain hemorrhage from a ruptured aneurysm: one group will receive more liberal red blood cell (RBC) transfusions while the other will follow a more restrictive approach. The goal is to see which strategy better improves outcomes and survival.See study design
What are the potential side effects?
Potential side effects may include reactions related to blood transfusions such as allergic responses, fever, iron overload in the body, lung injury from fluid overload, and increased risk of infections.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have had a brain aneurysm bleed for the first time.
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I have been diagnosed with a brain hemorrhage due to a ruptured aneurysm.
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I am 18 years or older.
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My hemoglobin was 100g/L or less within 10 days after my brain hemorrhage.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months post
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months post for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Modified Rankin Scale (mRS)
Secondary outcome measures
Cerebral Infarction
Daily Hemoglobin
Delayed Cerebral Ischemia and Vasospasm
+7 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Liberal RBC Transfusion StrategyExperimental Treatment1 Intervention
Hemoglobin value of ≤100g/L
Group II: Restrictive RBC Transfusion StrategyActive Control1 Intervention
Hemoglobin value of ≤80g/L

Find a Location

Who is running the clinical trial?

Ottawa Hospital Research InstituteLead Sponsor
561 Previous Clinical Trials
2,784,951 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,336 Previous Clinical Trials
25,750,368 Total Patients Enrolled
Shane English, MD MSc FRCPCPrincipal InvestigatorOttawa Hospital Research Institute
1 Previous Clinical Trials
60 Total Patients Enrolled

Media Library

Liberal RBC Transfusion Strategy Clinical Trial Eligibility Overview. Trial Name: NCT03309579 — N/A
Brain Aneurysm Research Study Groups: Liberal RBC Transfusion Strategy, Restrictive RBC Transfusion Strategy
Brain Aneurysm Clinical Trial 2023: Liberal RBC Transfusion Strategy Highlights & Side Effects. Trial Name: NCT03309579 — N/A
Liberal RBC Transfusion Strategy 2023 Treatment Timeline for Medical Study. Trial Name: NCT03309579 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How widely is this medical research being conducted in the US?

"Currently, 16 different medical centres are enrolling patients. These include sites in Montréal, Vancouver and Chicago among many others. It is wise to select the nearest site to reduce travel demand for participants of this trial."

Answered by AI

How many participants are included in the current clinical trial?

"To satisfactorily complete this trial, 740 individuals that meet the requisite qualifications need to sign up. Specifically, those looking for a medical centre in Canada can participate from Centre hospitalier de l'Université de Montréal or Vancouver General Hospital."

Answered by AI

Are there currently any vacancies in the study for participants?

"Affirmative. Clinicaltrials.gov displays that this research project, which was published on February 12th 2018 and amended most recently on September 9th 2021, is currently recruiting participants. Approximately 740 individuals must be recruited from 16 distinct sites."

Answered by AI

Who else is applying?

What state do they live in?
Georgia
What site did they apply to?
Emory University School of Medicine
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1
~104 spots leftby Mar 2025