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Diagnostic Imaging

Methodology for Heart Failure (LUPE Trial)

N/A
Waitlist Available
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Presence of peripheral edema with a score of at least 1+ (slight pitting in both ankles; 2mm or less depression that disappears rapidly)
Able to lie supine with no more than one pillow (approximately a 10 cm head elevation) without dyspnea for at least 30 minutes by patient report
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1
Awards & highlights

LUPE Trial Summary

This trial will test whether lung ultrasound can be used to measure extravascular lung water in stabilized patients during hospitalization for acute heart failure.

Eligible Conditions
  • Acute Heart Failure

LUPE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have swelling in your ankles that leaves a slight pit when pressed on, but it goes away quickly.
Select...
You can comfortably lie flat on your back with just one pillow (about 10 cm high) for at least 30 minutes without feeling short of breath, according to what you tell us.

LUPE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in B-line score

LUPE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Stable ADHF patientsExperimental Treatment1 Intervention
Lung ultrasound to access b lines
Group II: Control PatientsActive Control1 Intervention
Patients without any cardiopulmonary disease will be control patients for the active subjects, age-matched accordingly.

Find a Location

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
1,992 Previous Clinical Trials
42,875,345 Total Patients Enrolled
42 Trials studying Heart Failure
7,499 Patients Enrolled for Heart Failure
GlaxoSmithKlineIndustry Sponsor
4,742 Previous Clinical Trials
8,066,346 Total Patients Enrolled
20 Trials studying Heart Failure
54,814 Patients Enrolled for Heart Failure

Media Library

Lung Ultrasound (Diagnostic Imaging) Clinical Trial Eligibility Overview. Trial Name: NCT03146754 — N/A
Heart Failure Research Study Groups: Stable ADHF patients, Control Patients
Heart Failure Clinical Trial 2023: Lung Ultrasound Highlights & Side Effects. Trial Name: NCT03146754 — N/A
Lung Ultrasound (Diagnostic Imaging) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03146754 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any current openings for this clinical experiment?

"According to the clinicaltrials.gov listing, this trial is no longer open for enrollment. Initially posted on May 4th 2017, it was last updated December 1st 2022 and subsequently closed. Despite that fact, there are still 703 other research projects looking for participants at present."

Answered by AI
~2 spots leftby Mar 2025