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Transcatheter Mitral Valve Repair Device

Transcatheter mitral valve repair for Mitral Valve Regurgitation (EVOLVE-MR Trial)

N/A
Waitlist Available
Led By Anita W Asgar, MD
Research Sponsored by Montreal Heart Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Moderate functional mitral regurgitation (2+, 2-3+)
Left ventricular ejection fraction >20%
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

EVOLVE-MR Trial Summary

This study is evaluating whether a new treatment for heart failure can improve patients' functional capacity.

Eligible Conditions
  • Mitral Valve Regurgitation
  • Heart Failure
  • Mitral Regurgitation

EVOLVE-MR Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

EVOLVE-MR Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Functional capacity as measured by 6 minute walk test
Left ventricular diastolic remodelling
Secondary outcome measures
Mitral regurgitation Severity (EROA)
Mitral regurgitation Severity (RV)
Quality of Life Measurement

EVOLVE-MR Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Transcatheter Mitral valve repairExperimental Treatment1 Intervention
MitraClip treatment
Group II: Guideline-directed medical therapyPlacebo Group1 Intervention
Standard guideline-directed medical treatment for heart failure

Find a Location

Who is running the clinical trial?

Montreal Heart InstituteLead Sponsor
120 Previous Clinical Trials
68,645 Total Patients Enrolled
Abbott Medical DevicesIndustry Sponsor
635 Previous Clinical Trials
404,887 Total Patients Enrolled
Anita W Asgar, MDPrincipal InvestigatorMontreal Heart Institute

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~29 spots leftby Mar 2025