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Amino Acid

Acetyl-L-Carnitine for Friedreich Ataxia

N/A
Waitlist Available
Led By Theresa A Zesiewicz, MD
Research Sponsored by University of South Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up every 12 months, up to 24 months
Awards & highlights

Study Summary

The purpose of this study is to learn how treatment with acetyl-L-carnitine (ALCAR) will affect the hearts of patients with Friedreich's Ataxia as well as how it may affect other symptoms of Friedreich's Ataxia such as difficulties with balance, walking, or upper arm function.

Eligible Conditions
  • Friedreich Ataxia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~every 12 months, up to 24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and every 12 months, up to 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Friedreich Ataxia
To observe the changes in cardiac functioning in patients with Friedreich's Ataxia between study endpoint and baseline.
Secondary outcome measures
Changes in Time 25-foot Walk
Changes in clinical global impression of improvement
Changes in frequency and severity of adverse events
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Acetyl-L-CarnitineExperimental Treatment1 Intervention
Open-label administration of Acetyl-L-Carnitine, up to 2 g/day for 24 months.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Acetylcarnitine
FDA approved

Find a Location

Who is running the clinical trial?

University of South FloridaLead Sponsor
407 Previous Clinical Trials
186,789 Total Patients Enrolled
3 Trials studying Friedreich Ataxia
62 Patients Enrolled for Friedreich Ataxia
Theresa A Zesiewicz, MDPrincipal InvestigatorUniversity of South Florida
5 Previous Clinical Trials
33 Total Patients Enrolled
1 Trials studying Friedreich Ataxia
4 Patients Enrolled for Friedreich Ataxia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
An Open-label Study of the Effects of Acetyl-L-Carnitine on Cardiovascular Outcomes in Friedreich's Ataxia
Theresa Zesiewicz 2013. "An Open-label Study of the Effects of Acetyl-L-Carnitine on Cardiovascular Outcomes in Friedreich's Ataxia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01921868.
All > Friedreichs Ataxia > Cardiovascular
~2 spots leftby Apr 2025
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