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TMS to medial prefrontal cortex followed by TMS to lateral prefrontal cortex for Executive Function (NANCY Trial)

N/A
Waitlist Available
Led By Flavio Frohlich, PhD
Research Sponsored by University of North Carolina, Chapel Hill
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Healthy
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 hours
Awards & highlights

NANCY Trial Summary

This trial looks at how brain circuitry affects goal-directed behavior. Participants will do a task while brain stimulation and MRI are used to observe brain activity.

NANCY Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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You are in good health with no medical conditions.

NANCY Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percentage of the trials that the participant chooses to perform the hard task
Secondary outcome measures
Coupling strength between low-frequency prefrontal signals and high-frequency posterior signals

NANCY Trial Design

2Treatment groups
Experimental Treatment
Group I: TMS to medial prefrontal cortex followed by TMS to lateral prefrontal cortexExperimental Treatment3 Interventions
Participants will receive TMS while performing a reward-based decision-making task. In the first stimulation session, the TMS coil will be placed over the medial prefrontal cortex on the scalp. In the second session, the TMS coil will be placed over the lateral prefrontal cortex on the scalp. during every session, subjects receive Delta-beta patterned TMS, Theta-gamma patterned TMS, and Arrhythmic TMS.
Group II: TMS to lateral prefrontal cortex followed by TMS to medial prefrontal cortexExperimental Treatment3 Interventions
Participants will receive TMS while performing a reward-based decision-making task. In the first stimulation session, the TMS coil will be placed over the lateral prefrontal cortex on the scalp. In the second session, the TMS coil will be placed over the medial prefrontal cortex on the scalp. during every session, subjects receive Delta-beta patterned TMS, Theta-gamma patterned TMS, and Arrhythmic TMS.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Arrhythmic TMS
2023
N/A
~110
Delta-beta TMS
2023
N/A
~50
Theta-gamma TMS
2023
N/A
~50

Find a Location

Who is running the clinical trial?

University of North Carolina, Chapel HillLead Sponsor
1,498 Previous Clinical Trials
4,176,160 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,774 Previous Clinical Trials
2,674,349 Total Patients Enrolled
Flavio Frohlich, PhDPrincipal InvestigatorUniversity of North Carolina, Chapel Hill
19 Previous Clinical Trials
669 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any new openings for individuals wanting to join this research endeavor?

"This experiment is not currently looking for volunteers, as inferred from the clinicaltrials.gov database. Initially posted on November 30th 2022 and last updated on October 21st 2022, this study has since been superseded by 14 other trials actively seeking patients."

Answered by AI

Does the recruitment criteria permit individuals aged 35 or more to participate in this experiment?

"As stipulated in the enrollment requirements, only individuals between 18 and 35 years of age are allowed to participate."

Answered by AI

Does this clinical trial allow for my enrollment?

"We are searching for 24 intellectually capable individuals, aged 18 to 35 years old. In order to qualify as a participant of this trial, one must be in good health and demonstrate the capacity to provide informed consent. Furthermore, they need to be right-handed English speakers who can commit fully to all required study procedures."

Answered by AI
~23 spots leftby Mar 2025