← Back to Search

yoga for Major Depressive Disorder

N/A
Waitlist Available
Led By Chris Conway Streeter, MD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
If subjects have been taking antidepressants that target a monoamine system, the dose has been stable for at least three months with no anticipated changes during the study
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up screening, scan 1, scan 2, weeks 4, 8, 12 evaluations and follow-up at 2 and 6 months.
Awards & highlights

Study Summary

This trial is testing a new way to treat Major Depressive Disorder by using yoga or walking to fix an imbalance in the Autonomic Nervous System. This could provide relief for MDD and other disorders relevant to the Veteran population.

Eligible Conditions
  • Depression
  • Major Depressive Disorder
  • Post-Traumatic Stress Disorder

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
If you take antidepressants that target a specific system in the brain, you must have taken the same dose for at least three months with no plans to change the dose during the study.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~screening, scan 1, scan 2, at week 4, 8, 12 and follow-up at 2 and 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and screening, scan 1, scan 2, at week 4, 8, 12 and follow-up at 2 and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Hamilton Depression Rating Scales Change
Secondary outcome measures
Gamma Amino Butyric Acid (GABA) Change
Other outcome measures
Beck Depression Inventory II (BDI-II)
Brief Pain Inventory (BPI)
Clinician Administered Posttraumatic Stress Scale (CAPS)
+5 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Iyengar yoga and coherent breathingExperimental Treatment1 Intervention
The yoga intervention consists of Iyengar yoga method and coherent breathing sessions for 90 minutes twice a week or a maximum of 24 interventions over the 12 week intervention.
Group II: WalkingActive Control1 Intervention
The walking intervention consists of walking sessions at 2.5 miles an hour on a flat surface for 60 minutes twice a week or a maximum of 24 interventions over the 12 week intervention.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
yoga
2017
Completed Phase 2
~610

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,605 Previous Clinical Trials
3,305,594 Total Patients Enrolled
Chris Conway Streeter, MDPrincipal InvestigatorVA Bedford HealthCare System, Bedford, MA

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is participation in this trial restricted to individuals under twenty years of age?

"In line with the requirements for this trial, only adults aged 18 and above but below 65 years may be admitted."

Answered by AI

How many participants are currently being recruited for this clinical experiment?

"Affirmative. Clinicaltrials.gov's records indicate that this medical trial, first posted on January 27th 2020, is presently enrolling participants. 84 people need to be recruited from two distinct medical centres for the study to reach completion."

Answered by AI

Who is allowed to partake in the research protocol?

"This study requires 84 individuals with involutional psychosis to take part. Candidates should meet the following prerequisites: Diagnosed Major Depressive Disorder (MDD) as determined by MINI, females must use a reliable form of contraception, no changes in monoamine-targeting antidepressant medication over three months prior to enrollment, English fluency and comprehension of trial risks/benefits outlined in post-consent quiz, not pregnant nor plan on becoming so during the investigation period, HDRS score below 14 at screening stage, stable psychotherapy for last 3 months which excludes time limited treatments such as CBT , valid contact information provided plus completion"

Answered by AI

Are there any unfilled vacancies in this experiment?

"Clinicaltrials.gov data indicates that this study is actively seeking participants with its original posting dating back to January 27th 2020 and last amended on November 9th 2021."

Answered by AI

Who else is applying?

What state do they live in?
Massachusetts
How old are they?
18 - 65
What site did they apply to?
Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA
What portion of applicants met pre-screening criteria?
Met criteria
~1 spots leftby Mar 2025