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Healthy Exercise for Depression

N/A
Waitlist Available
Led By Bernadette Murphy, PhD
Research Sponsored by University of Ontario Institute of Technology
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
all participants must have no contraindications to exercise, be considered 'low active' (exercise less than 3 times per week for less than 20 minutes), MRI safe MDD group must be diagnosed by psychiatrist based on DSM-V criteria and pharmacological medication stabilized for a minimum of 6 weeks
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up eight weeks
Awards & highlights

Study Summary

To investigate the impact of a structured eight week exercise intervention as an add-on therapy in treating Major Depressive Disorder. Using behavioural techniques and neuroimaging to measure changes in brain function following an exercise intervention in people with clinical depression. By correlating changes in the hippocampus with changes in HPA axis hormones, inflammatory cytokines and growth factors it is possible to determine which of the biochemical markers is most predictive of improved neural function.

Eligible Conditions
  • Depression

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~eight weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and eight weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Brain function during an associative memory task
Secondary outcome measures
Anxiety
Biochemical markers
Depression scores
+2 more

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: MDD exercise groupExperimental Treatment1 Intervention
This group will receive eight weeks of moderate exercise in addition to their usual treatment
Group II: Healthy ExerciseExperimental Treatment1 Intervention
This group will perform an eight week moderate intensity exercise intervention
Group III: Healthy controlActive Control1 Intervention
This group will not perform exercise
Group IV: MDD control groupActive Control1 Intervention
This group will receive usual care with no exercise
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Exercise
2016
Completed Phase 1
~760

Find a Location

Who is running the clinical trial?

University of Ontario Institute of TechnologyLead Sponsor
7 Previous Clinical Trials
1,366 Total Patients Enrolled
Bernadette Murphy, PhDPrincipal InvestigatorUniversity of Ontario Institute of Technology

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~4 spots leftby Mar 2025