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Personalized Nutrition for Depression

N/A
Waitlist Available
Led By Karen M Davison, PhD
Research Sponsored by Karen Davison
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Male or female subjects who are living in the community and 19 years of age or older.
Mild to moderate depression as measured by the Quick Inventory of Depressive Symptomology (QIDS10).
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Study Summary

To evaluate the feasibility of nutrigenomics as an intervention for mental health conditions, a phase I randomized controlled trial of 42 adults (19 to 50 years) with depressive disorders using a 2:1 ratio of group selection (28 in the intervention {I} group and 14 in the control {C} group) is proposed. Participants with a confirmed depressive disorder will be recruited from two local mental health clinics. Those randomized into the I group will do the gene testing and be provided personalized DNA-based dietary advice from a registered dietitian; those in the C group will also receive testing but be given general dietary advice by a registered dietitian. Pre- and post-intervention comparisons (3 and 6 weeks after a personalized nutrition plan is given) will be analyzed based on records of dietary intakes (i.e., 3 day food records and food frequency questionnaire) and psychiatric functioning (e.g., Quick Inventory of Depressive Symptomology, Hospital Anxiety and Depression Scale, Outcome Questionnaire - OQ-45). In addition, measures that track physical activity, sedentary behavior, and sleep quality as well as sociodemographics will be included as covariates. After the intervention study is completed, in-depth focus group interviews will be conducted. Participants will be asked questions that will elicit their perceptions of the nutrigenomics test and the personalized dietary advice provided as well as the behavioural response to disclosure of genetic information.

Eligible Conditions
  • Depression

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Outcome Questionnaire-45
Secondary outcome measures
Changes in healthy eating index scores
General self-efficacy scale
Hospital Anxiety and Depression Scale
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Personalized NutritionExperimental Treatment1 Intervention
Participant receives gene test results with diet plan (personalized nutrition)
Group II: Gene Test Report OnlyPlacebo Group1 Intervention
Participant receives standard diet plan

Find a Location

Who is running the clinical trial?

Karen DavisonLead Sponsor
Karen M Davison, PhDPrincipal InvestigatorKwantlen Polytechnic University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~6 spots leftby Mar 2025