← Back to Search

Nonspecific Supportive Therapy (PBO) for Depression

N/A
Waitlist Available
Led By Jürgen Kayser, PhD
Research Sponsored by New York State Psychiatric Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
recruited to achieve equal gender representation (i.e. about half male) in both treatment arms
score greater or equal to 13 on the Beck Depression Inventory (BDI-II)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks or up to 12 weeks
Awards & highlights

Study Summary

This trial is testing how well CBT works for depression by looking at how people process emotions before and after treatment.

Eligible Conditions
  • Depression

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
The study will recruit an equal number of men and women in order to achieve gender balance in both groups receiving treatment.
Select...
If you score greater or equal to 13 on the Beck Depression Inventory (BDI-II), you may be experiencing depression.
Select...
The Hamilton Rating Scale for Depression (HRSD) is a tool used to measure the severity of depression in adults
Select...
You are aged 18 to 65 years.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-treatment, at baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-treatment, at baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
BDI slope
CP source (post)
CP source (pre)
+7 more
Secondary outcome measures
REA Fused Words (post)
REA Fused Words (pre)
Other outcome measures
CGI week 0
CGI week 1
CGI week 10
+10 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Nonspecific Supportive Therapy (PBO)Experimental Treatment1 Intervention
As a non-CBT intervention that includes warmth, genuineness and empathy (Linde et al., 2011), nonspecific supportive therapy (PBO) will be administered in a parallel format to CBT, also consisting of 12 individual sessions.
Group II: Cognitive Behavior Therapy (CBT)Experimental Treatment1 Intervention
Following established procedures at the Depression Evaluation Service (DES) at New York State Psychiatri Institute (NYSPI), 12 sessions of individual manual-driven CBT (Emery, 2000) will be conducted by highly trained master degree clinicians.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive Behavior Therapy (CBT)
2006
N/A
~340
Nonspecific Supportive Therapy (PBO)
2020
N/A
~50

Find a Location

Who is running the clinical trial?

New York State Psychiatric InstituteLead Sponsor
474 Previous Clinical Trials
153,216 Total Patients Enrolled
81 Trials studying Depression
10,072 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,774 Previous Clinical Trials
2,674,262 Total Patients Enrolled
665 Trials studying Depression
251,978 Patients Enrolled for Depression
Jürgen Kayser, PhDPrincipal Investigator - NYSPI/RFM/CU
New York State Psychiatric Institute

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research require participants to be of a certain age?

"The age limit for patients that want to enroll in this particular trial is 18-65."

Answered by AI

Why did researchers design this investigation in this way?

"The goal of this study is to improve participants' BDI scores by week 12. Secondary outcomes that will be measured over the same time frame include REA Fused Words at week 0, TAS at week 6, and REA Fused Words again at week 12."

Answered by AI

Are researchers still looking for study participants?

"That is accurate, the clinicaltrials.gov listing for this trial says that it is currently looking for 60 more participants. The listing also notes that the study was first posted on November 25th 2020 and last updated June 22nd 2022."

Answered by AI

What are the requirements to enroll in this clinical trial?

"Eligible participants for this trial must be between 18-65 years old, have a diagnosis of melancholia, and there are around 60 slots open."

Answered by AI

Who else is applying?

What state do they live in?
New York
What site did they apply to?
New York State Psychiatric Institute
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

I recently had to increase the dose of the SSRI that I have been taking for approx 30 years. Was also prescribed several additional Rx’s (benzodiazepines etc) and found side effects did not outweigh benefits.
PatientReceived no prior treatments
~9 spots leftby Mar 2025