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Triple Chronotherapy for Major Depressive Disorder (TCT-RCT Trial)

N/A
Waitlist Available
Led By Diane Hurd, PMHNP
Research Sponsored by Billings Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up phq-a the day prior to total sleep deprivation, and then again over the next 3 consecutive days, at 1-month and at 2-month
Awards & highlights

TCT-RCT Trial Summary

This trial is testing whether Transcranial Magnetic Stimulation (TMS) is an effective treatment for depression, suicidality, and insomnia in adolescents, compared to usual care.

Eligible Conditions
  • Major Depressive Disorder
  • Depression, Bipolar Disorder
  • Suicidal Thoughts

TCT-RCT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~phq-a the day prior to total sleep deprivation, and then again over the next 3 consecutive days, at 1-month and at 2-month
This trial's timeline: 3 weeks for screening, Varies for treatment, and phq-a the day prior to total sleep deprivation, and then again over the next 3 consecutive days, at 1-month and at 2-month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Columbia Suicide Severity Rating Scale
Patient Health Questionnaire -Adolescent version (PHQ-A)
Secondary outcome measures
Patient Health Questionnaire-Adolescent version (PHQ-A)
Youth Quality of life Questionnaire

TCT-RCT Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Triple ChronotherapyExperimental Treatment1 Intervention
Four-day intervention, with 24-hour total sleep deprivation, 3-days of sleep phase advancement and daily bright light therapy.
Group II: Treatment as UsualActive Control1 Intervention
Normal inpatient care, including pharmacotherapy, psychotherapy, milieu therapy and social work interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Triple Chronotherapy
2019
N/A
~110

Find a Location

Who is running the clinical trial?

Billings ClinicLead Sponsor
5 Previous Clinical Trials
457 Total Patients Enrolled
Jamie Besel, MSNStudy ChairBillings Clinic
Laurie Riemann, BSNStudy DirectorBillings Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any remaining enrolment opportunities in this clinical trial?

"Per the data found on clinicaltrials.gov, this experiment is presently recruiting participants. This investigation was initially posted to the website on January 25th 2019 and has since been amended as of July 7th 2022."

Answered by AI

Could I enlist in this medical experiment?

"This research project is looking for 108 adolescents, aged between 12 and 17, who have been diagnosed with moderate to severe depression. Suicidal ideation must be present in order to qualify as a candidate. Furthermore, the PHQ-A testing tool will evaluate whether or not each applicant has sufficient levels of severity; any individual obtaining a score close or higher than ten points indicates that they meet this criteria. Informed assent from the participant themselves plus parental consent are mandatory requirements for enrolment into the trial."

Answered by AI

What is the upper threshold of participants for this medical experiment?

"Affirmative. According to information posted on clinicaltrials.gov, this medical study is currently enlisting applicants for participation. The trial was first launched on the 25th of January 2019 and last updated on July 7th 2022; 108 subjects are needed at a single location."

Answered by AI

Is participation in this research study limited to those under 25 or are older individuals also welcome?

"This medical trial is targeting adolescents aged 12 to 17. Evidenced by the number of studies available, 224 for minors and 1062 for seniors, there are multiple trials that cater to different age groups."

Answered by AI
Recent research and studies
~10 spots leftby Mar 2025