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Behavioral Activation for Depression (ACT Trial)

N/A
Waitlist Available
Led By Jessica L Jenness, MD
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
current diagnosis of clinical depression (minor or major) will be recruited as study participants in the Behavioral Activation (BA) Group
history of exposure to childhood adversity (e.g., abuse, neglect, violent victimization)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up symptoms will be measured weekly throughout the study (weeks 1-12) and at a 3-month follow-up (week 24). diagnoses will be measure pre (week 0), post treatment (week 12), and at a 3-month follow-up (week 24).
Awards & highlights

ACT Trial Summary

This trial is testing whether Behavioral Activation, or BA, may be an alternative depression intervention for adolescents who have a history of Childhood Maltreatment, or CM. CM is defined as exposure to physical, sexual, or emotional abuse or physical or emotional neglect. This study will take an innovative approach integrating neural, behavioral, and novel mobile technologies to measure longitudinal change in reward processing as a mechanism of BA intervention response among depressed adolescents with a history of CM.

ACT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You cannot participate in the study if you are currently diagnosed with depression (minor or major) and are part of the Behavioral Activation (BA) group.
Select...
You have experienced difficult and traumatic events during your childhood such as abuse, neglect or violence.

ACT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~symptoms will be measured weekly throughout the study (weeks 1-12) and at a 3-month follow-up (week 24). diagnoses will be measure pre (week 0), post treatment (week 12), and at a 3-month follow-up (week 24).
This trial's timeline: 3 weeks for screening, Varies for treatment, and symptoms will be measured weekly throughout the study (weeks 1-12) and at a 3-month follow-up (week 24). diagnoses will be measure pre (week 0), post treatment (week 12), and at a 3-month follow-up (week 24). for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Anhedonia
Behavioral Activation-Passive
Depression
+3 more
Secondary outcome measures
Anxiety
Behavioral Problems
Hopelessness
+1 more

ACT Trial Design

1Treatment groups
Experimental Treatment
Group I: Behavioral Activation ArmExperimental Treatment1 Intervention
See treatment description for information on Behavioral Activation. Participants will receive 12 weekly sessions of Behavioral Activation.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Behavioral Activation
2013
Completed Phase 3
~2980

Find a Location

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,730 Previous Clinical Trials
1,841,953 Total Patients Enrolled
83 Trials studying Depression
87,345 Patients Enrolled for Depression
Seattle Children's HospitalOTHER
299 Previous Clinical Trials
5,216,738 Total Patients Enrolled
7 Trials studying Depression
809 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,775 Previous Clinical Trials
2,673,714 Total Patients Enrolled
665 Trials studying Depression
251,413 Patients Enrolled for Depression

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who can apply to partake in this clinical experiment?

"The parameters for this trial necessitate that the participants struggle with depression and range from 12 to 18 years old. The team is actively recruiting a total of 60 individuals."

Answered by AI

What are the desired outcomes of this medical research?

"The primary endpoint evaluated over the 12-week investigative period, as well as a 3-month follow up at Week 24 is Neural Reward Sensitivity. Secondary outcomes comprise of changes in commonly co-morbid behavioural problems with depression (i.e., attention deficit/hyperactivity disorder, conduct issues and oppositionality), alterations to anxiety symptoms and diagnoses, plus modifications to suicidal ideation, plans and behaviours along with self-harm thoughts and actions assessed through semi-structured interviews and questionnaires."

Answered by AI

Are individuals still able to join this research endeavor?

"The trial, initially posted on March 1st 2018 and last updated July 19th 2022, is not currently recruiting participants. However, data hosted on clinicaltrials.gov reveals that there are presently 1136 other medical studies actively enlisting patients."

Answered by AI

Does the current protocol of this research include seniors as participants?

"This research is interested in obtaining participants aged between 12 and 18 years old."

Answered by AI

Who else is applying?

What state do they live in?
Washington
How old are they?
18 - 65
What site did they apply to?
Seattle Children's Hospital
What portion of applicants met pre-screening criteria?
Met criteria
~10 spots leftby Mar 2025