CLINICAL TRIAL

Living Well for Depression

EnrollingByInvitation · 18+ · All Sexes · Tyler, TX

This study is evaluating whether a digital intervention can help reduce symptoms of depression and anxiety.

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About the trial for Depression

Eligible Conditions
Depression · Anxiety · Depressive Symptomatology · Emotional Disorders

Treatment Groups

This trial involves 2 different treatments. Living Well is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Living Well
BEHAVIORAL
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Living Well
2010
N/A
~400

Eligibility

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Mildly to moderately elevated symptoms of depression or anxiety as reflected by DASS-21 Depression (5-10) or Anxiety scores (4-7).
Undergraduate students aged 18 or older
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Measured at baseline
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Measured at baseline.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Living Well will improve 4 primary outcomes and 3 other outcomes in patients with Depression. Measurement will happen over the course of Measured at baseline.

Cognitive Fusion Questionnaire
MEASURED AT BASELINE
The Cognitive Fusion Questionnaire is a self report measure of cognitive fusion consisting of seven items. Higher scores indicate greater cognitive fusion and scores can range from 7 to 49.
Valuing Questionnaire-Progress Scale repeated measure of change
PRE-INTERVENTION, TWO WEEK POST INTERVENTION, AND FOUR WEEK POST INTERVENTION
Valuing Questionnaire-Progress Scale (VQ-P) is a five item scale assessing the extent to which one made progress towards one's values that is a part of the ten item Valuing Questionnaire. Higher scores on the VQ-P indicate greater progress towards one's values and VQ-P scores can range from 0 to 30.
Brief Experiential Avoidance Questionnaire repeated measure of change
PRE-INTERVENTION, TWO WEEK POST INTERVENTION, AND FOUR WEEK POST INTERVENTION
Brief Experiential Avoidance Questionnaire (BEAQ) is a 15 item self report measure assessing experiential avoidance. Higher scores on the BEAQ indicate greater experiential avoidance. Scores on the BEAQ can range from 15 to 90.
COVID-19 Impact Indicators repeated measure of change
MEASURED AT BASELINE, 2 WEEKS POST BASELINE, AND 4 WEEKS POST BASELINE
Participants will provide information on how they have been impacted by the COVID-19 pandemic. They will respond to the question "How has the COVID-19 outbreak affected you in the past two weeks (you can select multiple options)" selecting from among 10 possible options: Diagnosed with COVID-19, worked remotely or from home more than you usually do, worked more hours than usual, worked reduced hours, was not able to work, had difficulty arranging for childcare, incurred increased costs for childcare expenses, income or pay has been reduced, not paid at all, had serious financial problems. Participants may choose between 0 and 10 possible COVID-19 impacts. These do not belong to a standardized questionnaire, but have been used by other researchers to describe the impact of COVID-19.
Depression Anxiety Stress Scales-21 Depression Scale repeated measure of change
PRE-INTERVENTION, TWO WEEK POST INTERVENTION, AND FOUR WEEK POST INTERVENTION
Depression Anxiety Stress Scales-21 (DASS-21) is a 21 item self report questionnaire assessing symptoms of depression, anxiety, and stress. The DASS-21 seven item Depression Scale will be used to assess symptoms of depression and with higher scores indicating greater depressive symptoms. Scores on the DASS-21 Depression Scale range from 0 to 21.
Treatment Experience/Perceived Need Questions
MEASURED AT BASELINE
Participants will respond to three questions about past experience with mental health treatment and perceived future need with yes/no responses. These questions do not belong to a standardized questionnaire, but have been used by other researchers to describe participant experience. In the past 12 months, did you receive therapy from a professional counselor or therapist to help you with emotional or mental health problems such as feeling sad, blue, anxious, or nervous? In the past 12 months, did a healthcare professional prescribe medications to help you with emotional or mental health problems such as feeling sad, blue, anxious, or nervous? In the past 12 months, did you think you needed help for emotional or mental health problems such as feeling sad, blue, anxious, or nervous?
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Who is running the study

Principal Investigator
O. B.
Prof. Olga Berkout, Assistant Professor of Psychology
University of Texas at Tyler

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for depression?

Common treatments for depression can be grouped into the following categories: medications, psychotherapy, and self-help measures.\n\nThe medications used to treat depression generally belong to one of the following categories: selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs). Antidepressant drugs can produce rapid-onset, sustained effects in the short-term. They may even decrease suicidal tendencies, depending on the particular individual. Although antidepressant drugs are effective and often effective, depressive symptoms sometimes recur after a person has taken an antidepressant. Moreover, they must be taken continuously to be effective and most people require different classes of antidepressants.

Anonymous Patient Answer

What is depression?

Depressive symptoms such as feelings of sadness, feeling depressed with no real reason, and difficulty in concentrating may occur because of an underlying disease. However, because most people who are depressed experience symptoms such as low energy, slowed body movements, and loss of interest in usual activities we recommend looking for and treating any symptoms of depression that occur. Although the diagnosis of depression can be challenging, recognizing the manifestations of depression before they become clinically significant will help to facilitate appropriate treatment. It is important to recognize that there are multiple reasons why people feel sad: the lack of support from caregivers, failure in school, unemployment or a lack of personal or social supports, relationship problems or abuse, illness or discomfort at home.

Anonymous Patient Answer

Can depression be cured?

Depression should not be managed in conventional psychiatric units with drug therapy alone. Instead it should be managed by integrating it into other treatments within a multimodal approach. It is important for clinicians practicing in this area to recognize the importance of the role that a proper psychoeducation and motivational strategy plays in the treatment.

Anonymous Patient Answer

What are the signs of depression?

There are three main signs of depression: psychomotor retardation, excessive sleepiness and loss of interest, especially in the recent past, which is a significant symptom in diagnosing clinical depression. If these three signs exist, the case may be considered as depression with psychiatric comorbidity.

Anonymous Patient Answer

What causes depression?

Depression, regardless of the cause, has a significant negative impact on a person's quality of life and is associated with an array of poor physical and psychosocial outcomes. In those with a diagnosable mental illness (major depressive disorder or anxiety disorder), those whose depression is secondary to a demonstrable medical condition are even more likely to have physical comorbidities.

Anonymous Patient Answer

How many people get depression a year in the United States?

More than a million people are affected with clinically significant depressive symptoms annually in the US; the number of new cases of depression is estimated to increase by half annually and is the single biggest cause of disability and diminished quality of life in the US. Preventative efforts that focus on minimizing disability and improving quality of life through increased treatment are critical to achieving national goals of reducing the burden of depression on public health.

Anonymous Patient Answer

Does depression run in families?

There were no differences in the prevalence of depression between family members and the general student population. Depression was correlated with the family history of psychiatric disorders. The association of parental depression and subsequent adolescent depression was strongest in the group of adolescents whose parents were depressed. These family-based associations suggest a genetic component to depression and indicate the clinical importance of early detection and treatment of psychiatric symptoms among teenagers with an affected parent.

Anonymous Patient Answer

Has living well proven to be more effective than a placebo?

In a recent study, findings of the present study should be interpreted with caution, since the comparison group was living and in remission at the end of treatment. However, from the results it deserves to be concluded that even a slight deterioration of psychiatric symptoms and well-being does not necessarily have to be a bad thing. On the contrary it can be a benefit for patients if they have to face problems or difficulties.

Anonymous Patient Answer

Have there been any new discoveries for treating depression?

Antidepressants used for depression were found in one experiment to cause depression in rats as a dose-dependent effect that could be alleviated by a low dose of moclobemide. A number of additional findings have been published by the U.S. National Institute on Mental Health since the last publication on that topic. The latest findings from U.S. studies are not new in terms of treatment efficacy and safety. Most of our treatments for depression have always worked effectively for thousands of years, regardless of whether we have had our brains turned inside out for the past 20 - 30 years in terms of our knowledge of neuroscience and what’s happening.

Anonymous Patient Answer

How serious can depression be?

Depression, when severe, leads to suicide, as shown by the data from the UK's National Hospital Discharge Survey. The risk of suicide should help prompt the clinician to consider the serious possibility that depression is leading to or precipitating other psychiatric conditions or medical events.

Anonymous Patient Answer

What is the latest research for depression?

In a recent study, findings indicates that information about depression is changing and that the research field is at risk of compromising information that is the most relevant to patients.

Anonymous Patient Answer

What is the average age someone gets depression?

If prevalence rates are assumed to be comparable between countries, the most common age at onset of depression is 21.4 years worldwide. Depressed women appear to develop depression a few years earlier than men.

Anonymous Patient Answer
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