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Sleep-Based Memory Reactivation for Memory Consolidation

N/A
Recruiting
Led By Anna C Schapiro, PhD
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Ages between 18 and 35
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up in aim 1, accuracy is collected in a missing feature task 25 min. into the experiment, taking 25 min. in aim 2, accuracy is collected in a missing feature task over 25 min in stage 2
Awards & highlights

Study Summary

This trial will test whether structure in semantic knowledge is abstract, allowing generalization and inference in novel environments, and whether sleep-based consolidation is needed for this.

Who is the study for?
This trial is for healthy individuals aged between 18 and 35 who have no medical or neurological illnesses that could affect their performance in the study. It's not open to members of vulnerable populations.Check my eligibility
What is being tested?
The study tests how sleep affects learning abstract information. Participants will learn categories with structured relations, then researchers will see if sleep helps them transfer this knowledge to new sets of features using EEG and memory reactivation techniques.See study design
What are the potential side effects?
Since this trial involves non-invasive procedures like EEG monitoring and targeted memory reactivation during sleep, side effects are minimal but may include discomfort from wearing an EEG cap or disrupted sleep due to experimental interventions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 35 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~in aim 1, accuracy is collected in a missing feature task 25 min. into the experiment, taking 25 min. in aim 2, accuracy is collected in a missing feature task over 25 min in stage 2
This trial's timeline: 3 weeks for screening, Varies for treatment, and in aim 1, accuracy is collected in a missing feature task 25 min. into the experiment, taking 25 min. in aim 2, accuracy is collected in a missing feature task over 25 min in stage 2 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Structure knowledge for a new Modular category in Stage 2

Trial Design

7Treatment groups
Experimental Treatment
Group I: Sleep IncongruentExperimental Treatment3 Interventions
Participants will learn two different semantic categories, one of which has a Modular structure. After a 2-hour nap opportunity, during which TMR will be used to reactivate the non-Modular category, participants will take a 30-minute break. After the break, they will learn and be tested on a novel semantic category with a Modular structure.
Group II: Sleep Congruent (SWS)Experimental Treatment3 Interventions
Participants will learn two different semantic categories, one of which has a Modular structure. After a 2-hour nap opportunity, during which TMR will be used to reactivate the Modular category during slow wave sleep (SWS), participants will take a 30-minute break. After the break, they will learn and be tested on a novel semantic category with a Modular structure.
Group III: Sleep Congruent (REM)Experimental Treatment3 Interventions
Participants will learn two different semantic categories, one of which has a Modular structure. After a 2-hour nap opportunity, during which TMR will be used to reactivate the Modular category during rapid eye movement (REM) sleep, participants will take a 30-minute break. After the break, they will learn and be tested on a novel semantic category with a Modular structure.
Group IV: Immediate IncongruentExperimental Treatment2 Interventions
Participants will learn and be tested on two different semantic categories with different structures that dictate the co-occurrence of different features.
Group V: Immediate CongruentExperimental Treatment2 Interventions
Participants will learn and be tested on two different semantic categories with the same structure that dictates the co-occurrence of different features.
Group VI: Awake IncongruentExperimental Treatment2 Interventions
Participants will learn two different semantic categories, neither of which has a Modular structure. After a 2.5-hour break, they will learn and be tested on a novel semantic category with a Modular structure.
Group VII: Awake CongruentExperimental Treatment2 Interventions
Participants will learn two different semantic categories, one of which has a Modular structure. After a 2.5-hour break, they will learn and be tested on a novel semantic category with a Modular structure.

Find a Location

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
1,993 Previous Clinical Trials
42,875,313 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,775 Previous Clinical Trials
2,673,494 Total Patients Enrolled
Anna C Schapiro, PhDPrincipal InvestigatorUniversity of Pennsylvania
1 Previous Clinical Trials
105 Total Patients Enrolled

Media Library

Immediate Congruent Clinical Trial Eligibility Overview. Trial Name: NCT05746299 — N/A
Memory Consolidation Research Study Groups: Immediate Congruent, Immediate Incongruent, Awake Incongruent, Awake Congruent, Sleep Incongruent, Sleep Congruent (SWS), Sleep Congruent (REM)
Memory Consolidation Clinical Trial 2023: Immediate Congruent Highlights & Side Effects. Trial Name: NCT05746299 — N/A
Immediate Congruent 2023 Treatment Timeline for Medical Study. Trial Name: NCT05746299 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research endeavor have an upper age limit for participation?

"This research seeks to enroll individuals between the ages of majority and 35 years old."

Answered by AI

How many participants have been invited to partake in this clinical experiment?

"Confirmed. Clinicaltrials.gov states that this medical trial, posted on March 9th 2023 and last updated February 14th 2023, is in need of 250 participants from one site."

Answered by AI

Does this research project have any available openings?

"According to information available on clinicaltrials.gov, the trial posted on March 9th of 2023 is still searching for participants. An update was made most recently on February 14th of that same year."

Answered by AI

What eligibility criteria are necessary to participate in this clinical trial?

"To be eligible to take part in this research, applicants must demonstrate the capacity for cognitive consolidation during sleep and meet age requirements (18-35). In total, 250 participants are required."

Answered by AI
~50 spots leftby Jun 2024