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Fatiguing Exercise for COPD

N/A
Waitlist Available
Led By François Maltais, MD
Research Sponsored by Laval University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
COPD with FEV1/FVC < 0.70 and FEV1 < 0.80 predicted
Healthy subjects with no evidence of airways obstruction (FEV1/FVC > 0.70 and FEV1 > 0.80 predicted)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 45 seconds post-exercise (knee extension repetitions)
Awards & highlights

Study Summary

This trial will investigate whether localized exercise results in greater limb muscle fatigue for COPD patients due to reduced oxygen and metabolism levels.

Who is the study for?
This trial is for COPD patients with a specific lung function profile and a history of smoking, as well as healthy individuals without airway obstruction. It's not for those who are very active, overweight, have recent serious health issues like heart disease or cancer, engage in regular exercise, or have severe breathing problems at rest.Check my eligibility
What is being tested?
The study is testing how localized fatiguing exercise affects muscle fatigue in COPD patients by looking at changes in muscle oxygenation and metabolism. The goal is to see if reduced cardiorespiratory demand leads to greater limb muscle fatigue.See study design
What are the potential side effects?
Since the intervention involves fatiguing exercise, participants may experience increased breathlessness, temporary muscle soreness or cramps during or after the activity. However, these side effects are typically mild and short-lived.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have COPD with specific lung function test results.
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My lung function tests show I don't have airway blockage.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 15 min and 40 min after the fatigue-inducing exercise
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 15 min and 40 min after the fatigue-inducing exercise for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Muscle deoxygenation
Muscle metabolism
Secondary outcome measures
Quadriceps muscle fatigue
Ventilatory response
total muscle work

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: OxygenExperimental Treatment1 Intervention
Group II: Room airPlacebo Group1 Intervention

Find a Location

Who is running the clinical trial?

Laval UniversityLead Sponsor
416 Previous Clinical Trials
172,256 Total Patients Enrolled
Canadian Lung AssociationIndustry Sponsor
9 Previous Clinical Trials
65,645 Total Patients Enrolled
François Maltais, MDPrincipal InvestigatorInstitut universitaire de cardiologie et de pneumologie de Québec, University Laval
12 Previous Clinical Trials
424 Total Patients Enrolled

Media Library

Fatiguing exercise Clinical Trial Eligibility Overview. Trial Name: NCT01909544 — N/A
Chronic Obstructive Pulmonary Disease Research Study Groups: Oxygen, Room air
Chronic Obstructive Pulmonary Disease Clinical Trial 2023: Fatiguing exercise Highlights & Side Effects. Trial Name: NCT01909544 — N/A
Fatiguing exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT01909544 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Do I fulfill the criteria to take part in this examination?

"This clinical trial seeks to recruit 20 individuals aged between 50 and 75 with a history of chronic airflow obstruction. Patients must have COPD (FEV1/FVC < 0.70 and FEV1 < 0.80 predicted) or be healthy subjects (no evidence of airways obstruction, i.e., FEV1/FVC > 0.70 and FEV1 > 0.80 predicted). Additionally, participants should possess a smoking record exceeding 15 pack-years in duration."

Answered by AI

Is enrollment to this trial still ongoing?

"Contrary to what is listed on clinicaltrials.gov, this trial is not presently looking for participants. It was posted in September 2011 and last updated in February 2014; however, there are 677 other trials that currently require patients."

Answered by AI

Is there an age restriction for participating in this medical experiment?

"This trial is specifically seeking out elderly participants aged 50-75 years old."

Answered by AI
~1 spots leftby Mar 2025