Fatiguing exercise for Airflow Obstruction, Chronic

Waitlist Available · 18+ · All Sexes · Québec, Canada

This study is evaluating whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequence of muscle oxygenation and muscle metabolism disturbances.

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About the trial for Airflow Obstruction, Chronic

Eligible Conditions
Lung Diseases · Pulmonary Disease, Chronic Obstructive · Chronic Disease · Fatigue

Treatment Groups

This trial involves 2 different treatments. Fatiguing Exercise is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Fatiguing exercise
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Fatiguing exercise


This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Smoking history > 15 pack-years
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Odds of Eligibility
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: baseline, 15 min and 40 min after the fatigue-inducing exercise
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: baseline, 15 min and 40 min after the fatigue-inducing exercise.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Fatiguing exercise will improve 2 primary outcomes and 3 secondary outcomes in patients with Airflow Obstruction, Chronic. Measurement will happen over the course of baseline, 15 min and 40 min after the fatigue-inducing exercise.

Quadriceps muscle fatigue
Quadriceps muscle fatigue will be determined by loss of quadriceps strength measured by magnetic stimulation after the fatigue-inducing exercise. Surface electromyography will also be measured to characterize muscle fatigue.
total muscle work
Total muscle work performed during fatigue-inducing exercise that will be composed by subsequent isokinetic knee-extensions repetitions at 40% of maximal peak torque
Muscle metabolism
Changes in glycolytic and oxidative metabolism pathway markers, energy substrates (glycogen and glucose), end-products of glycolysis (pyruvate, and lactate), intermediate markers of glycolysis and high-energy phosphate compounds obtained from muscle biopsies
Muscle deoxygenation
Changes of deoxyhemoglobin/myoglobin concentrations measured by near-infrared spectroscopy of vastus lateralis muscle.
Ventilatory response
Minute ventilation will be monitored during the fatigue-inducing exercise and it will be compared between subjects and conditions (FiO2 = 21% vs. FiO2 = 100%)

Who is running the study

Principal Investigator
F. R.
Fernanda Ribeiro, PhD candidate
Laval University

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of airflow obstruction, chronic?

Breath sounds from the lung, especially rales, and coughing up blood, both suggestive of airflow obstruction are often accompanied by the aforementioned clinical signs. However, airflow obstruction alone is often overshadowed by related features: heart failure and arteriosclerosis, both causing cough; and cardiac tamponade, causing tachypnea.

Anonymous Patient Answer

What are common treatments for airflow obstruction, chronic?

There is no evidence of a single'standard' therapy for COPD. Instead, there are several different options that may be combined. Patients with mild and moderate obstruction can experience symptom control and improved quality of life via a modest decrease in airflow obstruction, including reduction in breathlessness, better exercise tolerance, and improved health status.

Anonymous Patient Answer

What is airflow obstruction, chronic?

Airflow obstruction by itself is not the cause of chronic airflow disorders in smokers. The airflow obstruction is a result of the interaction between smoking and other pulmonary comorbidities such as emphysema.

Anonymous Patient Answer

How many people get airflow obstruction, chronic a year in the United States?

Approximately 5.0 million people in the United States have airflow obstruction, chronic due to asthma or COPD. This type of narrowing of the airways reduces airflow causing respiratory symptoms. It represents a significant burden when considering the burden of disease in the United States.

Anonymous Patient Answer

Can airflow obstruction, chronic be cured?

A positive correlation between post-treatment FEV(1) and the duration of [smoking cessation]( and the age at which cigarette smoking was begun is observed. Early cessation of smoking, both in smokers with chronic airflow obstruction and with normal values, might reduce airflow obstruction and improve outcome. A longer duration of smoking cessation (≥5 years) before the onset of chronic airflow obstruction (age >55) might have similar effects on clinical outcome.

Anonymous Patient Answer

What causes airflow obstruction, chronic?

The obstructive syndrome of chronic airflow obstruction is associated with an exaggerated response to inhaled agonists, but this does not appear to be as far-reaching as the hypothesis of impaired control of airway smooth muscle. Findings from a recent study suggest that: 1) chronic airflow obstruction is a physiological disorder in which the response to inhaled stimuli is markedly exaggerated, 2) the abnormal responses that we demonstrate are attributable rather to increased responsiveness to beta agonists, and 3) the responses are not due to impaired control of airway smooth muscle. In accordance with our hypothesis, the responses to methacholine remain normal in all three of these subjects with obstructive syndrome.

Anonymous Patient Answer

How serious can airflow obstruction, chronic be?

In patients hospitalized for a severe community-acquired pneumonia, airflow obstruction is as common as the pneumonia. The clinical presentation of COPD is not always characterized by a low baseline lung function. Patients with chronic airflow obstruction are at high risk of death.

Anonymous Patient Answer

Is fatiguing exercise safe for people?

Results from a recent clinical trial of this study indicate that exercise is safe as regards major cardiovascular outcomes in subjects with CAD or CAD with significant disease-related airways obstruction, but the findings did not identify exercise as an independent risk factor for cardiac death.

Anonymous Patient Answer

What are the common side effects of fatiguing exercise?

Exercise induced side effects depend heavily on the intensity and duration of exercise. To minimize these side effects, it is necessary to perform exercise with the body at optimum intensity and minimize exercise times exceeding 1 hour.

Anonymous Patient Answer

Have there been other clinical trials involving fatiguing exercise?

Results from a recent paper, the combined findings are consistent with the hypothesis that the beneficial effects of brief bouts of severe or moderate exercise on airway patency and lung function in patients with airway obstruction were at least in part mediated by vasodilation.

Anonymous Patient Answer

Does fatiguing exercise improve quality of life for those with airflow obstruction, chronic?

Despite the well-documented effects of aerobic exercise on respiratory muscle function and exercise capacity, this intervention has not been shown to be beneficial to the QoL of patients with airflow obstruction, chronic health conditions.

Anonymous Patient Answer

Who should consider clinical trials for airflow obstruction, chronic?

The percentage of the total population with airflow obstruction, chronic who are eligible for a clinical trial of drug therapy could be markedly increased by eliminating, for example, those at significant risk of sudden cardiac death. A decision support system based on a simple risk scoring system may be used to identify individuals at increased risk of sudden cardiac death for whom clinical trials have a clear therapeutic rationale, based on a recent risk-benefit analysis.

Anonymous Patient Answer
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