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exercise intervention for Breast Cancer

N/A
Waitlist Available
Led By Jessica Clague DeHart
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Any body mass index (BMI)
The study will be conducted in women who have been diagnosed with a first primary invasive estrogen receptor (ER) positive (+) breast cancer (stages I-IIIa) who are within the first 3 years post-treatment
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 16 weeks
Awards & highlights

Study Summary

This trial is testing whether an exercise intervention can help prevent breast cancer from coming back in postmenopausal survivors.

Eligible Conditions
  • Breast Cancer
  • Postmenopausal
  • Cancer Survivors

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~16 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 16 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in 60 minutes mean olive tail moments measured by the Comet assay
Change in level of interleukin-6 (IL-6) cytokine measured by the 13 Plex-Immunology Multiplex Assay by EMD Millipore
Change in telomerase activity using the Trypan blue method and ImagedQuant
Secondary outcome measures
Adherence to the study protocol
Change in C-reactive protein (CRP) and levels of cytokines measured by the 13 Plex-Immunology Multiplex Assay by EMD Millipore
Change in telomere length as measured by quantitative polymerase chain reaction
+9 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Arm I (exercise intervention)Experimental Treatment4 Interventions
Patients participate in a supervised Curves exercise program three days a week for 16 weeks. The circuit-style workout consists of 14 exercises constructed with pneumatic or hydraulic resistance that target opposing muscle groups in a concentric-only fashion. Each session at Curves will include two complete circuits which correspond to exercising for approximately 30 minutes followed by a standardized stretching routine.
Group II: Arm II (no formal exercise intervention)Active Control1 Intervention
Patients do not participate in a formal exercise program for 16 weeks. Patients are then offered the Curves exercise intervention.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
exercise intervention
2013
N/A
~1060

Find a Location

Who is running the clinical trial?

City of Hope Medical CenterLead Sponsor
560 Previous Clinical Trials
1,918,002 Total Patients Enrolled
43 Trials studying Breast Cancer
6,649 Patients Enrolled for Breast Cancer
National Cancer Institute (NCI)NIH
13,613 Previous Clinical Trials
40,918,265 Total Patients Enrolled
939 Trials studying Breast Cancer
1,543,333 Patients Enrolled for Breast Cancer
Jessica Clague DeHartPrincipal InvestigatorCity of Hope Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are researchers currently enrolling volunteers for this experiment?

"As documented on clinicaltrials.gov, the recruitment period for this medical trial has concluded. The study was initially posted on September 7th 2014 and last adjusted in March 17th 2022. Though no longer looking for participants, there are over 2,300 other active studies searching for patients right now."

Answered by AI

What objectives is this research trying to fulfill?

"The primary purpose of this 16-week trial is to measure changes in telomerase activity with Trypan blue and ImagedQuant. In addition, secondary outcomes encompass functional capacity (assessed using repeated measures ANOVA), telomere length (quantified through quantitative PCR paired t-tests) along with cardiopulmonary function (also evaluated via repeated measures ANOVA). Further analysis may be conducted to account for any potential confounding factors related to differences between the two groups such as body mass index or exercise intensity."

Answered by AI
~5 spots leftby Mar 2025