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3D-CRT

Proton APBI for Breast Cancer

Phase 2
Waitlist Available
Led By Robert Mutter, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Willing to provide tissue and blood samples for correlative research purposes
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 3 years
Awards & highlights

Study Summary

This trial will test a new, three-fraction daily dosing regimen for accelerated partial breast irradiation (APBI) to see if it is safe and effective.

Eligible Conditions
  • Breast Cancer

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are willing to give samples of your tissue and blood for research purposes.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in the Rate of Adverse Cosmesis (Defined as Fair or Poor Cosmesis) Compared to Baseline Using the Harvard Cosmetic Rating

Trial Design

3Treatment groups
Experimental Treatment
Group I: Proton APBIExperimental Treatment1 Intervention
7.3 Gy x 3 fractions
Group II: Catheter-based brachytherapy APBIExperimental Treatment1 Intervention
7 Gy x 3 fractions
Group III: 3D-CRT APBIExperimental Treatment1 Intervention
7.3 Gy x 3 fractions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Brachytherapy APBI
2015
Completed Phase 2
~170
Proton APBI
2015
Completed Phase 2
~170
3D-CRT (photon) APBI
2015
Completed Phase 2
~170

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,176 Previous Clinical Trials
3,757,881 Total Patients Enrolled
82 Trials studying Breast Cancer
13,866 Patients Enrolled for Breast Cancer
Robert Mutter, MDPrincipal InvestigatorMayo Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available openings to partake in this experiment?

"The clinical trial in question has been posted on clinicaltrials.gov since June 16th, 2015 and was last updated November 11th 2022; however, it is not currently seeking participants. Fortunately, there are 2602 other trials actively recruiting subjects at this time."

Answered by AI
~17 spots leftby Mar 2025